Effect of clonidine on growth hormone and glucagon secretion.

The effect of clonidine (0.15 mg i.v.) on circulating GH, glucagon and glucose concentrations was measured in six normal subjects. GH and glucose increased but glucagon secretion remained unchanged. These data indicate that in man clonidine-induced GH secretion is not mediated by a stimulatory effect of clonidine on glucagon secretion and that alpha-adrenergic mechanisms have little role in the regulation of basal glucagon secretion.