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Literature DB >> 7307344

The immunological measurements of 'free' secretory piece and its relationship to local IgA production.

Abstract

Free secretory piece (FSP) was studied in the sputum of patients with chronic bronchitis. The concentrations were higher both in the presence of infection and when greater quantities of total secretory piece were present compared to the amount of 11S IgA. A significant inverse correlation was found between the amount of FSP and 11S IgA in the individual samples when standardized for their total secretory piece content (2P less than 0 . 01). This suggests that the amount of FSP in any sample is partly dependent upon the amount of 11S IgA. The techniques employed offer a method for the study of the secretory IgA system in biological fluids. The preliminary results suggest that the secretory IgA system is independent of the systemic IgA system.

Entities: Disease Gene Species

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Year: 1981 PMID： 7307344 PMCID： PMC1537265

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

14 in total

1. Preparation of a monospecific antiserum to thyroxine binding globulin for its quantitation by rocket immunoelectrophoresis.

Authors: A R Bradwell; D Burnett; D B Ramsden; W A Burr; H P Prince; R Hoffenberg
Journal: Clin Chim Acta Date: 1976-09-20 Impact factor: 3.786

2. Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage.

Authors: H Y Reynolds; H H Newball
Journal: J Lab Clin Med Date: 1974-10

3. Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors: G Mancini; A O Carbonara; J F Heremans
Journal: Immunochemistry Date: 1965-09

4. Secretory component deficiency. A disorder of the IgA immune system.

Authors: W Strober; R Krakauer; H L Klaeveman; H Y Reynolds; D L Nelson
Journal: N Engl J Med Date: 1976-02-12 Impact factor: 91.245

5. Synthesis of immunoglobulin and secretory component by gastrointestinal mucosa in patients with hypogammaglobulinaemia or IgA deficiency.

Authors: D B McClelland; D J Shearman; R Van Furth
Journal: Clin Exp Immunol Date: 1976-07 Impact factor: 4.330

Review 6. Mucosal immunology.

Authors: J Bienenstock; A D Befus
Journal: Immunology Date: 1980-10 Impact factor: 7.397

3. The secretory IgA system of lung secretions in chronic obstructive bronchitis: comparison of sputum with secretions obtained during fibreoptic bronchoscopy.

Authors: J Wiggins; S L Hill; R A Stockley
Journal: Thorax Date: 1984-07 Impact factor: 9.139

7. The concentrations of IgA and free secretory piece in the nasal secretions of patients with recurrent respiratory infections.

Authors: P J Stanley; P J Cole
Journal: Clin Exp Immunol Date: 1985-01 Impact factor: 4.330

7 in total

The immunological measurements of 'free' secretory piece and its relationship to local IgA production.

1. Preparation of a monospecific antiserum to thyroxine binding globulin for its quantitation by rocket immunoelectrophoresis.

2. Analysis of proteins and respiratory cells obtained from human lungs by bronchial lavage.

3. Immunochemical quantitation of antigens by single radial immunodiffusion.

4. Secretory component deficiency. A disorder of the IgA immune system.

5. Synthesis of immunoglobulin and secretory component by gastrointestinal mucosa in patients with hypogammaglobulinaemia or IgA deficiency.

Review 6. Mucosal immunology.

7. Free secretory component and other proteins in human lung lavage.

8. Alpha,-antitrypsin and leukocyte elastase in infected and noninfected sputum.

9. A study of plasma proteins in the sol phase of sputum from patients with chronic bronchitis.

10. Differential quantification of SIgA and SC by two-directional rocket method.

1. Immunoglobulins in the lung.

Review 2. Measurement of soluble proteins in lung secretions.

3. The secretory IgA system of lung secretions in chronic obstructive bronchitis: comparison of sputum with secretions obtained during fibreoptic bronchoscopy.

4. Cells containing IgA subclasses in bronchi of subjects with and without chronic obstructive lung disease.

5. Intracellular and transcellular transport of secretory component and albumin in rat hepatocytes.

6. Lung secretion sol-phase proteins: comparison of sputum with secretions obtained by direct sampling.

7. The concentrations of IgA and free secretory piece in the nasal secretions of patients with recurrent respiratory infections.