Literature DB >> 7306939

Nickel carbonate induces DNA-protein crosslinks and DNA strand breaks in rat kidney.

R B Ciccarelli, T H Hampton, K W Jennette.   

Abstract

DNA lesions were observed in kidney nuclei isolated from rats 20 h after i.p. injection with nickel carbonate. Dose-dependent, nickel-induced DNA crosslinks and DNA single strand breaks were detected using the alkaline elution technique. The DNA crosslinks were determined to be completely DNA-protein in nature. The DNA damage induced by nickel carbonate is discussed relative to the carcinogenicity of nickel compounds.

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Year:  1981        PMID： 7306939     DOI： 10.1016/0304-3835(81)90178-6

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  6 in total

1.  Comparison of Transition Metal-Mediated Oxidation Reactions of Guanine in Nucleoside and Single-Stranded Oligodeoxynucleotide Contexts.

Authors:  Pranjali Ghude; Mark A Schallenberger; Aaron M Fleming; James G Muller; Cynthia J Burrows
Journal:  Inorganica Chim Acta       Date:  2011-04-15       Impact factor: 2.545

2.  Investigations of the frequency of DNA strand breakage and cross-linking and of sister chromatid exchange in the lymphocytes of electric welders exposed to chromium- and nickel-containing fumes.

Authors:  W Popp; C Vahrenholz; W Schmieding; E Krewet; K Norpoth
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015

3.  Chromosomal alterations in cell lines derived from mouse rhabdomyosarcomas induced by crystalline nickel sulfide.

Authors:  N T Christie; P Sen; M Costa
Journal:  Biol Met       Date:  1988

4.  In vitro assessment of the toxicity of metal compounds : III. Effects of metals on DNA structure and function in intact cells.

Authors:  N T Christie; M Costa
Journal:  Biol Trace Elem Res       Date:  1983-02       Impact factor: 3.738

Review 5.  Risk assessment of nickel carcinogenicity and occupational lung cancer.

Authors:  H M Shen; Q F Zhang
Journal:  Environ Health Perspect       Date:  1994-01       Impact factor: 9.031

6.  Transformation of human osteoblasts to anchorage-independent growth by insoluble nickel particles.

Authors:  X Lin; M Costa
Journal:  Environ Health Perspect       Date:  1994-09       Impact factor: 9.031
  6 in total

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