Literature DB >> 7306008

The activation of pyruvate dehydrogenase in the perfused rat heart by adrenaline and other inotropic agents.

J G McCormack, R M Denton.   

Abstract

Adrenaline resulted in a reversible 4-fold increase in the amount of pyruvate dehydrogenase in its active non-phosphorylated form in the perfused rat heart within 1 min. The increase was less in extent in hearts from starved or diabetic rats or in hearts from control rats oxidizing acetate, unless pyruvate was added to the perfusion medium. Increases could also be induced by other inotropic agents, supporting the hypothesis that increases in cytoplasmic Ca2+ can be relayed into mitochondria and influence oxidative metabolism.

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Year:  1981        PMID： 7306008      PMCID： PMC1162790          DOI： 10.1042/bj1940639

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Correlation between contraction and phosphorylation of the inhibitory subunit of troponin in perfused rat heart.

Authors:  P J England
Journal:  FEBS Lett       Date:  1975-01-15       Impact factor: 4.124

2.  METABOLIC EFFECTS OF EPINEPHRINE IN THE ISOLATED, PERFUSED RAT HEART. I. DISSOCIATION OF THE GLYCOGENOLYTIC FROM THE METABOLIC STIMULATORY EFFECT.

Authors:  J R WILLIAMSON
Journal:  J Biol Chem       Date:  1964-09       Impact factor: 5.157

3.  Pyruvate dehydrogenase activation after an increase in cardiac output.

Authors:  J A Illingworth; R Mullings
Journal:  Biochem Soc Trans       Date:  1976       Impact factor: 5.407

4.  Conversion of inactive (phosphorylated) pyruvate dehydrogenase complex into active complex by the phosphate reaction in heart mitochondria is inhibited by alloxan-diabetes or starvation in the rat.

Authors:  N J Hutson; A L Kerbey; P J Randle; P H Sugden
Journal:  Biochem J       Date:  1978-08-01       Impact factor: 3.857

5.  Effect of glucagon on cyclic 3',5'-AMP, phosphorylase activity and contractility of heart muscle of the rat.

Authors:  S E Mayer; D H Namm; L Rice
Journal:  Circ Res       Date:  1970-02       Impact factor: 17.367

6.  Metabolic effects of epinephrine in the perfused rat heart. I. Comparison of intracellular redox states, tissue pO2 and force of contraction.

Authors:  J R Williamson; D Jamieson
Journal:  Mol Pharmacol       Date:  1966-05       Impact factor: 4.436

7.  Mechanisms regulating adipose-tissue pyruvate dehydrogenase.

Authors:  B R Martin; R M Denton; H T Pask; P J Randle
Journal:  Biochem J       Date:  1972-09       Impact factor: 3.857

8.  Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide.

Authors:  A L Kerbey; P J Randle; R H Cooper; S Whitehouse; H T Pask; R M Denton
Journal:  Biochem J       Date:  1976-02-15       Impact factor: 3.857

9.  Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart.

Authors:  P J England
Journal:  Biochem J       Date:  1976-11-15       Impact factor: 3.857

10.  Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.

Authors:  S Whitehouse; R H Cooper; P J Randle
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857
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  20 in total

1.  Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans.

Authors:  M J Watt; K F Howlett; M A Febbraio; L L Spriet; M Hargreaves
Journal:  J Physiol       Date:  2001-07-01       Impact factor: 5.182

Review 2.  Mitochondrial Ca²⁺ homeostasis: mechanism, role, and tissue specificities.

Authors:  Paola Pizzo; Ilaria Drago; Riccardo Filadi; Tullio Pozzan
Journal:  Pflugers Arch       Date:  2012-06-16       Impact factor: 3.657

3.  Relation between cytosolic free Ca2+ concentration and the control of pyruvate dehydrogenase in isolated cardiac myocytes.

Authors:  R G Hansford
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

Review 4.  Dehydrogenase activation by Ca2+ in cells and tissues.

Authors:  R G Hansford
Journal:  J Bioenerg Biomembr       Date:  1991-12       Impact factor: 2.945

Review 5.  Role of mitochondrial Ca2+ in the regulation of cellular energetics.

Authors:  Brian Glancy; Robert S Balaban
Journal:  Biochemistry       Date:  2012-03-29       Impact factor: 3.162

Review 6.  Cardiac mitochondrial matrix and respiratory complex protein phosphorylation.

Authors:  Raul Covian; Robert S Balaban
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-08-10       Impact factor: 4.733

Review 7.  Nutrient sensing and utilization: Getting to the heart of metabolic flexibility.

Authors:  Timothy M Griffin; Kenneth M Humphries; Michael Kinter; Hui-Ying Lim; Luke I Szweda
Journal:  Biochimie       Date:  2015-10-22       Impact factor: 4.079

8.  Evidence that noradrenaline increases pyruvate dehydrogenase activity and decreases acetyl-CoA carboxylase activity in rat interscapular brown adipose tissue in vivo.

Authors:  J M Gibbins; R M Denton; J G McCormack
Journal:  Biochem J       Date:  1985-06-15       Impact factor: 3.857

9.  Occupancy of phosphorylation sites in pyruvate dehydrogenase phosphate complex in rat heart in vivo. Relation to proportion of inactive complex and rate of re-activation by phosphatase.

Authors:  G J Sale; P J Randle
Journal:  Biochem J       Date:  1982-08-15       Impact factor: 3.857

10.  The alpha-adrenergic-mediated activation of the cardiac mitochondrial Ca2+ uniporter and its role in the control of intramitochondrial Ca2+ in vivo.

Authors:  M Crompton; P Kessar; I Al-Nasser
Journal:  Biochem J       Date:  1983-11-15       Impact factor: 3.857
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