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Literature DB >> 7305990

Differential cytotoxicity of daunomycin in tumour cells is related to glutathione-dependent hydrogen peroxide metabolism.

A Bozzi, I Mavelli, B Mondovi, R Strom, G Rotilio.

Abstract

Addition of 0.5mm-daunomycin, a quinone anti-cancer drug, causes severe inhibition of respiration in Ehrlich ascites cells, whereas Yoshida ascites cells were almost as resistant as rat hepatocytes. An inverse relationship appears to exist in the two types of tumour cells (which are both catalase-deficient) between the extent of cellular damage brought about by intracellular formation of superoxide anion occurring on reaction with O(2) of the drug free radical and the efficiency of the glutathione-mediated H(2)O(2)-detoxifying system.

Entities: Chemical Disease Species

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Year: 1981 PMID： 7305990 PMCID： PMC1162754 DOI： 10.1042/bj1940369

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

11 in total

1. Adriamycin stimulated superoxide formation in submitochondrial particles.

Authors: W S Thayer
Journal: Chem Biol Interact Date: 1977-12 Impact factor: 5.192

2. A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

Authors: N R Bachur; S L Gordon; M V Gee
Journal: Cancer Res Date: 1978-06 Impact factor: 12.701

3. The univalent reduction of oxygen by reduced flavins and quinones.

Authors: H P Misra; I Fridovich
Journal: J Biol Chem Date: 1972-01-10 Impact factor: 5.157

4. Intracellular localization of superoxide dismutase and its relation to the distribution and mechanism of hydrogen peroxide-producting enzymes.

Authors: G Rotilio; L Calabrese; A Finazzi Agrò; M P Argento-Cerù; F Autuori; B Mondovì
Journal: Biochim Biophys Acta Date: 1973-09-15

5. Studies on the mechanism of inhibition by polyenic antibiotics of nucleic acid biosynthesis in ascites tumor cells.

Authors: R Strom; A Bozzi; A S Santoro; C Crifò; B Mondovì; A R Fanelli
Journal: Cancer Res Date: 1972-04 Impact factor: 12.701

6. Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.

Authors: D P Jones; H Thor; B Andersson; S Orrenius
Journal: J Biol Chem Date: 1978-09-10 Impact factor: 5.157

7. Isolation and use of liver cells.

Authors: P Moldéus; J Högberg; S Orrenius
Journal: Methods Enzymol Date: 1978 Impact factor: 1.600

8. Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation.

Authors: K Handa; S Sato
Journal: Gan Date: 1975-02

9. Enzyme defense against reactive oxygen derivatives. II. Erythrocytes and tumor cells.

Authors: A Bozzi; I Mavelli; A Finazzi; R Strom; A M Wolf; B Mondovi; G Rotilio
Journal: Mol Cell Biochem Date: 1976-01-31 Impact factor: 3.396

10. Differential sensitivity of tumor cells to externally generated hydrogen peroxide. Role of glutathione and related enzymes.

Authors: A Bozzi; I Mavelli; B Mondovì; R Strom; G Rotilio
Journal: Cancer Biochem Biophys Date: 1979

7 in total

7. An antioxidant, probucol, induces anti-angiogenesis and apoptosis in athymic nude mouse xenografted human head and neck squamous carcinoma cells.

Authors: G Nishimura; S Yanoma; H Mizuno; K Kawakami; M Tsukuda
Journal: Jpn J Cancer Res Date: 1999-11

7 in total

Differential cytotoxicity of daunomycin in tumour cells is related to glutathione-dependent hydrogen peroxide metabolism.

1. Adriamycin stimulated superoxide formation in submitochondrial particles.

2. A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

3. The univalent reduction of oxygen by reduced flavins and quinones.

4. Intracellular localization of superoxide dismutase and its relation to the distribution and mechanism of hydrogen peroxide-producting enzymes.

5. Studies on the mechanism of inhibition by polyenic antibiotics of nucleic acid biosynthesis in ascites tumor cells.

6. Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.

7. Isolation and use of liver cells.

8. Generation of free radicals of quinone group-containing anti-cancer chemicals in NADPH-microsome system as evidenced by initiation of sulfite oxidation.

9. Enzyme defense against reactive oxygen derivatives. II. Erythrocytes and tumor cells.

10. Differential sensitivity of tumor cells to externally generated hydrogen peroxide. Role of glutathione and related enzymes.

1. Superoxide dismutase, glutathione peroxidase and catalase in developing rat brain.

Review 2. Tumour cell resistance to anthracyclines--a review.

Review 3. Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation.

4. Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemia.

5. Biochemical mechanism of oxidative damage by redox-cycling drugs.

6. Toxicity of liposomal N-acyl daunorubicins to L929 cells in culture.

7. An antioxidant, probucol, induces anti-angiogenesis and apoptosis in athymic nude mouse xenografted human head and neck squamous carcinoma cells.