Literature DB >> 7305725

The sensitive period for induction of susceptibility to audiogenic seizures by kanamycin in mice.

C S Chen, G C Aberdeen.   

Abstract

It has been found that administration of kanamycin (400 mg/kg daily) for 5 days was highly effective in inducing susceptibility to audiogenic seizures in BALB/c mice, if the drug was administered between the age of 10-14 postnatal days. The same drug dosage administered between the age of 5-19, 15-19, or 20-24 postnatal days was found to be ineffective. Since induction of seizure susceptibility is highly correlated with the degree of cochlear damage produced by either ototoxic drugs or noise, it was suggested that the age of 10-14 postnatal days could be the most sensitive period for the ototoxic effect of kanamycin.

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Year:  1981        PMID： 7305725     DOI： 10.1007/bf00457444

Source DB:  PubMed          Journal:  Arch Otorhinolaryngol        ISSN： 0302-9530


  11 in total

1.  Effects of 6-aminonicotinamide on abolition and induction of audiogenic seizures.

Authors:  C Chen; G R Gates
Journal:  Exp Neurol       Date:  1977-12       Impact factor: 5.330

2.  Sensitization for audiogenic seizures in two strains of mice and their F1 hybrids.

Authors:  C S Chen
Journal:  Dev Psychobiol       Date:  1973-03       Impact factor: 3.038

3.  Effect of priming and tympanic membrane destruction on development of audiogenic seizure susceptibility in BALB-c mice.

Authors:  C S Chen; R Gates; G R Bock
Journal:  Exp Neurol       Date:  1973 Mar-Apr       Impact factor: 5.330

4.  Anatomy and physiology of the onset of auditory function.

Authors:  R Pujol; D Hilding
Journal:  Acta Otolaryngol       Date:  1973-07       Impact factor: 1.494

5.  The effects of priming for audiogenic seizures on cochlear and behavioral responses in BALB-c mice.

Authors:  J C Saunders; G R Bock; C S Chen; G R Gates
Journal:  Exp Neurol       Date:  1972-09       Impact factor: 5.330

6.  The development of the organ of Corti in the mouse.

Authors:  K Kikuchi; D Hilding
Journal:  Acta Otolaryngol       Date:  1965-09       Impact factor: 1.494

7.  Changes in cochlear microphonic sensitivity after priming C57BL/6j mice at various ages for audiogenic seizures.

Authors:  J C Saunders; K A Hirsch
Journal:  J Comp Physiol Psychol       Date:  1976-02

8.  Supra-normal sensitivity to ototoxic antibiotic of the developing rat cochlea.

Authors:  E Carlier; R Pujol
Journal:  Arch Otorhinolaryngol       Date:  1980

9.  Effects of kanamycin on the auditory evoked responses during postnatal development of the hearing of the rat.

Authors:  S Osako; T Tokimoto; S Matsuura
Journal:  Acta Otolaryngol       Date:  1979       Impact factor: 1.494

10.  Potentiation of noise-induced audiogenic seizure risk by salicylate in mice as a function of salicylate-noise exposure interval.

Authors:  C S Chen; G C Aberdeen
Journal:  Acta Otolaryngol       Date:  1980       Impact factor: 1.494
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  5 in total

1.  The postnatal development of stimulated deoxyglucose uptake into the mouse cochlea and the inferior colliculus.

Authors:  B Canlon; M Anniko
Journal:  Arch Otorhinolaryngol       Date:  1987

2.  Transplacental kanamycin ototoxicity in the guinea pig.

Authors:  Y Raphael; A Fein; L Nebel
Journal:  Arch Otorhinolaryngol       Date:  1983

3.  The sensitive period for ototoxicity of kanamycin in mice: morphological evidence.

Authors:  C S Chen; J C Saunders
Journal:  Arch Otorhinolaryngol       Date:  1983

4.  In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period.

Authors:  Shan Sun; Mingzhi Sun; Yanping Zhang; Cheng Cheng; Muhammad Waqas; Huiqian Yu; Yingzi He; Bo Xu; Lei Wang; Jian Wang; Shankai Yin; Renjie Chai; Huawei Li
Journal:  Front Cell Neurosci       Date:  2014-09-15       Impact factor: 5.505

5.  Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin.

Authors:  Lan Yao; Jing-Wei Zhang; Bin Chen; Ming-Min Cai; Dong Feng; Qi-Zhi Wang; Xin-Yu Wang; Jian-Guo Sun; Yi-Wen Zheng; Guang-Ji Wang; Fang Zhou
Journal:  Acta Pharmacol Sin       Date:  2020-01-14       Impact factor: 6.150
  5 in total

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