Literature DB >> 7305054

Evaluation of instrumented force platform as a test to measure residual effects of anesthetics.

K Korttila, M M Ghoneim, L Jacobs, R S Lakes.   

Abstract

Recovery from anesthesia was assessed in a controlled manner in 38 healthy student volunteers, using two psychomotor tests (perceptual speed and tapping board) and an instrumented force platform 1, 3, 5 and 7 h after intravenous injection of 0.3 mg/kg diazepam, 2.0 mg/kg methohexital, 6.0 mg/kg thiopental or saline. Postural stability remained unaltered but the performance on psychomotor tests improved when the tests were repeated after saline injection. Methohexital did not induce any changes in body sway or psychomotor performance at the time periods tested when compared with saline. Postural stability of subjects receiving thiopental or diazepam was imparied (P less than 0.001) for 1 and 7 hours after anesthesia, respectively, when compared with saline. The impairment on performance in the psychomotor tests induced by thiopental or diazepam was of smaller magnitude and for diazepam of shorter duration than balance disturbances measured with the body sway tests. Further clinical studies on the use of the instrumented force platform as a fast and easily interpretable guideline for discharge from hospital after different modes of outpatient anesthesia are warranted.

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Year:  1981        PMID: 7305054     DOI: 10.1097/00000542-198155060-00004

Source DB:  PubMed          Journal:  Anesthesiology        ISSN: 0003-3022            Impact factor:   7.892


  6 in total

1.  Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. I: Lorazepam.

Authors:  S K Gupta; E H Ellinwood; A M Nikaido; D G Heatherly
Journal:  J Pharmacokinet Biopharm       Date:  1990-04

2.  Practice Guidelines for Intravenous Conscious Sedation in Dentistry (Second Edition, 2017).

Authors: 
Journal:  Anesth Prog       Date:  2018

3.  Dose-response analysis of the behavioral effects of diazepam: II. Psychomotor performance, cognition and mood.

Authors:  M M Ghoneim; S P Mewaldt; J V Hinrichs
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

4.  Effect of flumazenil on disturbance of equilibrium function induced by midazolam.

Authors:  S Maeda; T Miyawaki; H Higuchi; M Shimada
Journal:  Anesth Prog       Date:  2008

Review 5.  Drug treatment as a cause of falls in old age. A review of the offending agents.

Authors:  A J Campbell
Journal:  Drugs Aging       Date:  1991 Jul-Aug       Impact factor: 3.923

6.  Recovery following general anesthesia with isoflurane or enflurane for outpatient dentistry and oral surgery.

Authors:  J V Valanne; K Korttila
Journal:  Anesth Prog       Date:  1988 Mar-Apr
  6 in total

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