Literature DB >> 7301686

A case of prenylamine toxicity showing the torsade de pointes phenomenon in sinus rhythm?

C I Meanock, M I Noble.   

Abstract

A case of torsade de pointes attributed to prenylamine is described. In addition, the authors show QRS axis variation of a similar nature in sinus rhythm. It is postulated that these changes of QRS axis direction, seen in ventricular tachycardia and sinus rhythm, are both manifestations of partial refractoriness, within the ventricle, producing gross changes in the mean QRS vector.

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Year:  1981        PMID： 7301686      PMCID： PMC2424893          DOI： 10.1136/pgmj.57.668.381

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  7 in total

1.  SOME APPLICATIONS OF PHYSIOLOGY TO MEDICINE: II.-VENTRICULAR FIBRILLATION AND SUDDEN DEATH.

Authors:  J A Macwilliam
Journal:  Br Med J       Date:  1923-08-11

2.  Torsade De Pointes, an atypical ventricular tachycardia.

Authors:  D M Krikler; P V Curry
Journal:  Br Heart J       Date:  1976-02

3.  Ventricular arrhythmias caused by prenylamine.

Authors:  R Puritz; M A Henderson; S N Baker; D A Chamberlain
Journal:  Br Med J       Date:  1977-09-03

4.  [Ventricular tachycardia with 2 variable opposing foci].

Authors:  F Dessertenne
Journal:  Arch Mal Coeur Vaiss       Date:  1966-02

5.  [Repeated syncopes during prolonged treatment with prenylamine (Segontine 60)].

Authors:  R Picard; P Auzepy; J P Chauvin
Journal:  Presse Med       Date:  1971-01-23       Impact factor: 1.228

6.  [Syncope by volley of ventricular spikes induced or encouraged by prenylamine].

Authors:  J L Bens; M Duboisset; J C Quiret; J P Lesbre; P Bernasconi
Journal:  Arch Mal Coeur Vaiss       Date:  1973-11

7.  [Adverse effects of drugs: syncope due to prenylamine (author's transl)].

Authors:  G Jacovella; F S Vajola
Journal:  G Ital Cardiol       Date:  1976
  7 in total
  3 in total

Review 1.  QT-interval prolonging drugs: mechanisms and clinical relevance of their arrhythmogenic hazards.

Authors:  M Zehender; S Hohnloser; H Just
Journal:  Cardiovasc Drugs Ther       Date:  1991-04       Impact factor: 3.727

2.  Ventricular tachycardia precipitated by sodium iothalamate (Conray 420) injection during prenylamine treatment: a predictable adverse drug interaction.

Authors:  J S Duncan; L E Ramsay
Journal:  Postgrad Med J       Date:  1985-05       Impact factor: 2.401

Review 3.  Withdrawal of prenylamine: perspectives on pharmacological, clinical and regulatory outcomes following the first QT-related casualty.

Authors:  Rashmi R Shah; Peter D Stonier
Journal:  Ther Adv Drug Saf       Date:  2018-06-18
  3 in total

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