Literature DB >> 7301598

Synthesis of 6-substituted thymine nucleosides.

M von Janta-Lipinski, P Langen.   

Abstract

The preparation of several N(1)-glycosyl derivatives of 6-fluorothymine is described. The displacement of the fluorine atom at the C-6-position of the heterocyclic component lead to a series of new 6-substituted 5-methyl-pyrimidine-2,4-dione-nucleosides. Some of these new compounds show significant virostatic activity against influenza A virus strains.

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Year:  1981        PMID: 7301598

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN: 0261-3166


  1 in total

1.  Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides.

Authors:  E Matthes; P Langen; M von Janta-Lipinski; H Will; H C Schröder; H Merz; B E Weiler; W E Müller
Journal:  Antimicrob Agents Chemother       Date:  1990-10       Impact factor: 5.191

  1 in total

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