Literature DB >> 7301597

The synthesis and properties of some 5-substituted uracil derivatives.

R T Walker, A S Jones, S G Rahim, P Serafinowski, E De Clercq.   

Abstract

The problems encountered in the synthesis of 5-vinyl-2'-deoxyuridine are outlined and the synthesis of 5-bromoethynyl-2'-deoxyuridine described. E-5-(2-Bromovinyl)-2'-deoxyuridine is the most potent and specific agent against some herpes viruses yet discovered; we have now synthesised the Z-isomer and this appears to be essentially biologically inert.

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Year:  1981        PMID： 7301597

Source DB:  PubMed          Journal:  Nucleic Acids Symp Ser        ISSN： 0261-3166


  3 in total

1.  Synthesis and biological properties of 2'-deoxy-5-vinyluridine and 2'deoxy-5-vinylcytidine.

Authors:  S G Rahim; M J Duggan; R T Walker; A S Jones; R L Dyer; J Balzarini; E De Clercq
Journal:  Nucleic Acids Res       Date:  1982-09-11       Impact factor: 16.971

2.  Synthesis of Novel 2-Thiouracil-5-Sulfonamide Derivatives as Potent Inducers of Cell Cycle Arrest and CDK2A Inhibition Supported by Molecular Docking.

Authors:  Samar S Fatahala; Amira I Sayed; Shahenda Mahgoub; Heba Taha; Mohamed-I Kotb El-Sayed; Mohamed F El-Shehry; Samir M Awad; Rania H Abd El-Hameed
Journal:  Int J Mol Sci       Date:  2021-11-04       Impact factor: 5.923

3.  5-Ethynyl-2'-deoxycytidine and 5-ethynyl-2'-deoxyuridine are differentially incorporated in cells infected with HSV-1, HCMV, and KSHV viruses.

Authors:  Salomé Manska; Rionna Octaviano; Cyprian C Rossetto
Journal:  J Biol Chem       Date:  2020-03-23       Impact factor: 5.157
  3 in total

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