Literature DB >> 7300594

Aqueous lipid phases of relevance to intestinal fat digestion and absorption.

M Lindström, H Ljusberg-Wahren, K Larsson, B Borgström.   

Abstract

The phase behavior of monoglyceride/water systems, with oleic and linoleic acid as the dominating fatty acid residues, was investigated. Increased solubilization of triglycerides (oil) or oleic acid in the cubic liquid-crystalline phase formed by monoglyceride and water resulted in the formation of a reversed hexagonal liquid-crystalline phase followed by an L2-phase. The liquid-crystalline phases have different dispersion properties compared to each other in dilute micellar bile salt solutions. The cubic phase is found to be easily dispersed. The relevance of aqueous lipid phases other than micellar is discussed in relation to intestinal lipid digestion and absorption.

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Year:  1981        PMID： 7300594     DOI： 10.1007/bf02535343

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  16 in total

1.  THE FUNCTION OF BILE SALTS IN FAT ABSORPTION. THE SOLVENT PROPERTIES OF DILUTE MICELLAR SOLUTIONS OF CONJUGATED BILE SALTS.

Authors:  A F HOFMANN
Journal:  Biochem J       Date:  1963-10       Impact factor: 3.857

2.  The behavior and solubility of monoglycerides in dilute, micellar bile-salt solution.

Authors:  A F HOFMANN
Journal:  Biochim Biophys Acta       Date:  1963-06-18

3.  Physico-chemical state of lipids in intestinal content during their digestion and absorption.

Authors:  A F HOFMANN; B BORGSTROM
Journal:  Fed Proc       Date:  1962 Jan-Feb

4.  A study of particulate intestinal absorption and hepatocellular uptake. Use of polystyrene latex particles.

Authors:  E SANDERS; C T ASHWORTH
Journal:  Exp Cell Res       Date:  1961-01       Impact factor: 3.905

5.  Studies of intestinal digestion and absorption in the human.

Authors:  B BORGSTROM; A DAHLQVIST; G LUNDH; J SJOVALL
Journal:  J Clin Invest       Date:  1957-10       Impact factor: 14.808

6.  The absorption of triglyceride fat from the intestine.

Authors:  A C FRAZER
Journal:  Physiol Rev       Date:  1946-01       Impact factor: 37.312

7.  Phase behavior of aqueous systems of monoglycerides.

Authors:  E S Lutton
Journal:  J Am Oil Chem Soc       Date:  1965-12       Impact factor: 1.849

8.  Isolation and properties of the mixed lipid micelles present in intestinal content during fat digestion in man.

Authors:  C M Mansbach; R S Cohen; P B Leff
Journal:  J Clin Invest       Date:  1975-10       Impact factor: 14.808

9.  Gastric lipolysis of human milk lipids in infants with pyloric stenosis.

Authors:  T Olivecrona; A Billström; B Fredrikzon; O Johnson; G Samuelson
Journal:  Acta Paediatr Scand       Date:  1973-09

10.  Watching fat digestion.

Authors:  J S Patton; M C Carey
Journal:  Science       Date:  1979-04-13       Impact factor: 47.728
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  13 in total

1.  Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs.

Authors:  Jean F Cuiné; William N Charman; Colin W Pouton; Glenn A Edwards; Christopher J H Porter
Journal:  Pharm Res       Date:  2007-02-15       Impact factor: 4.200

2.  Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering.

Authors:  Dimitrios G Fatouros; G Roshan Deen; Lise Arleth; Bjorn Bergenstahl; Flemming Seier Nielsen; Jan Skov Pedersen; Anette Mullertz
Journal:  Pharm Res       Date:  2007-04-26       Impact factor: 4.200

3.  Self-assembled structures formed during lipid digestion: characterization and implications for oral lipid-based drug delivery systems.

Authors:  Stephanie Phan; Stefan Salentinig; Clive A Prestidge; Ben J Boyd
Journal:  Drug Deliv Transl Res       Date:  2014-06       Impact factor: 4.617

Review 4.  Cubosomes: The Next Generation of Smart Lipid Nanoparticles?

Authors:  Hanna M G Barriga; Margaret N Holme; Molly M Stevens
Journal:  Angew Chem Int Ed Engl       Date:  2018-09-26       Impact factor: 15.336

5.  Colloidal inverse bicontinuous cubic membranes of block copolymers with tunable surface functional groups.

Authors:  Yunju La; Chiyoung Park; Tae Joo Shin; Sang Hoon Joo; Sebyung Kang; Kyoung Taek Kim
Journal:  Nat Chem       Date:  2014-05-11       Impact factor: 24.427

6.  A liquid crystalline phase in human intestinal contents during fat digestion.

Authors:  P R Holt; B M Fairchild; J Weiss
Journal:  Lipids       Date:  1986-07       Impact factor: 1.880

Review 7.  Cystic fibrosis--a gastroenterological cornucopia.

Authors:  P L Zentler-Munro
Journal:  Gut       Date:  1987-11       Impact factor: 23.059

8.  Bicontinuous cubic liquid crystalline nanoparticles for oral delivery of Doxorubicin: implications on bioavailability, therapeutic efficacy, and cardiotoxicity.

Authors:  Nitin K Swarnakar; Kaushik Thanki; Sanyog Jain
Journal:  Pharm Res       Date:  2013-11-12       Impact factor: 4.200

9.  Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation.

Authors:  Christopher J H Porter; Ann Marie Kaukonen; Ben J Boyd; Glenn A Edwards; William N Charman
Journal:  Pharm Res       Date:  2004-08       Impact factor: 4.200

10.  In vitro gastrointestinal lipolysis of four formulations of piroxicam and cinnarizine with the self emulsifying excipients Labrasol and Gelucire 44/14.

Authors:  Sylvie Fernandez; Stéphanie Chevrier; Nicolas Ritter; Bruno Mahler; Frédéric Demarne; Frédéric Carrière; Vincent Jannin
Journal:  Pharm Res       Date:  2009-05-19       Impact factor: 4.200
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