Literature DB >> 7299403

The extraneural distribution of gamma-hydroxybutyrate.

T Nelson, E Kaufman, J Kline, L Sokoloff.   

Abstract

gamma-Hydroxybutyrate has been found to be widely distributed in both neural and extraneural tissues in the rat. The kidney and brown fat have more than 10 times higher concentrations of gamma-hydroxybutyrate than does the brain. This observation suggests that gamma-hydroxybutyrate may participate in the metabolism of many organs, and that GABA may not be the precursor in extraneural tissues.

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Year:  1981        PMID: 7299403     DOI: 10.1111/j.1471-4159.1981.tb04689.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN: 0022-3042            Impact factor:   5.372


  22 in total

1.  Potential gamma-hydroxybutyric acid (GHB) drug interactions through blood-brain barrier transport inhibition: a pharmacokinetic simulation-based evaluation.

Authors:  Indranil Bhattacharya; Kathleen M K Boje
Journal:  J Pharmacokinet Pharmacodyn       Date:  2006-08-29       Impact factor: 2.745

Review 2.  An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP(+)-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway.

Authors:  E E Kaufman; T Nelson
Journal:  Neurochem Res       Date:  1991-09       Impact factor: 3.996

3.  Acute poisoning from gamma-hydroxybutyrate in California.

Authors:  M Y Chin; R A Kreutzer; J E Dyer
Journal:  West J Med       Date:  1992-04

4.  Behavioral effects of gamma-hydroxybutyrate in humans.

Authors:  Alison Oliveto; William Brooks Gentry; Rhonda Pruzinsky; Kishorchandra Gonsai; Thomas R Kosten; Bridget Martell; James Poling
Journal:  Behav Pharmacol       Date:  2010-07       Impact factor: 2.293

5.  gamma-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes.

Authors:  P Lorente; A Lacampagne; Y Pouzeratte; S Richards; B Malitschek; R Kuhn; B Bettler; G Vassort
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

Review 6.  gamma-Hydroxybutyrate/sodium oxybate: neurobiology, and impact on sleep and wakefulness.

Authors:  Daniel Pardi; Jed Black
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

Review 7.  Environmental alterations of epigenetics prior to the birth.

Authors:  Chiao-Ling Lo; Feng C Zhou
Journal:  Int Rev Neurobiol       Date:  2014       Impact factor: 3.230

8.  Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.

Authors:  Vincent P Kelly; Philip J Sherratt; Dorothy H Crouch; John D Hayes
Journal:  Biochem J       Date:  2002-09-15       Impact factor: 3.857

9.  Metabolism of [U-14C]-4-hydroxybutyric acid to intermediates of the tricarboxylic acid cycle in extracts of rat liver and kidney mitochondria.

Authors:  K M Gibson; W L Nyhan
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1989 Jan-Mar       Impact factor: 2.441

10.  Effects of L-lactate and D-mannitol on gamma-hydroxybutyrate toxicokinetics and toxicodynamics in rats.

Authors:  Qi Wang; Xiaodong Wang; Marilyn E Morris
Journal:  Drug Metab Dispos       Date:  2008-08-21       Impact factor: 3.922

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