Literature DB >> 7299377

Immunogenic effect of inactivated hepatitis B vaccine: comparison of 20 microgram and 40 microgram doses.

S Krugman, H P Holley, M Davidson, M S Simberkoff, N Matsaniotis.   

Abstract

The immunogenic effect of inactivated hepatitis B vaccine (Merck Heptavax B) was evaluated in 202 seronegative healthy medical personnel. Three inoculations of vaccine were given at 1-month intervals. Of 116 vaccinees who received a 40-microgram dose, 39% had an anti-HBs response 1 month after the first dose, 88% 1 month after the second dose, and 99% 1 month after the third dose. Of 86 vaccinees who received a 20 microgram dose, 40% had an anti-HBs response 1 month after the first dose, 79% after the second dose, and 95% after the third dose. These results confirm the high immunogenic effect of a 20-microgram dose of vaccine.

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Year:  1981        PMID： 7299377     DOI： 10.1002/jmv.1890080205

Source DB:  PubMed          Journal:  J Med Virol        ISSN： 0146-6615            Impact factor:   2.327


  10 in total

1.  Intradermal hepatitis B vaccine in thalassaemia and sickle cell disease.

Authors:  Q Mok; G Underhill; B Wonke; M Aldouri; M Kelsey; D Jefferies
Journal:  Arch Dis Child       Date:  1989-04       Impact factor: 3.791

2.  Immunogenicity of hepatitis B virus vaccine (Heptavax-B)--response of healthy adults.

Authors:  R P Beasley; L Y Hwang
Journal:  West J Med       Date:  1984-05

Review 3.  Priorities for immunisation against hepatitis B.

Authors:  A J Zuckerman
Journal:  Br Med J (Clin Res Ed)       Date:  1982-03-06

4.  Suboptimal response to hepatitis B vaccine in Nova Scotia.

Authors: 
Journal:  Can Med Assoc J       Date:  1985-08-15       Impact factor: 8.262

Review 5.  Hepatitis B vaccination during pregnancy for preventing infant infection.

Authors:  Ussanee S Sangkomkamhang; Pisake Lumbiganon; Malinee Laopaiboon
Journal:  Cochrane Database Syst Rev       Date:  2014-11-11

6.  Impaired responsiveness of homosexual men with HIV antibodies to plasma derived hepatitis B vaccine.

Authors:  C A Carne; I V Weller; J Waite; M Briggs; F Pearce; M W Adler; R S Tedder
Journal:  Br Med J (Clin Res Ed)       Date:  1987-04-04

7.  Expression of hepatitis B virus surface antigen in yeast.

Authors:  R A Hitzeman; C Y Chen; F E Hagie; E J Patzer; C C Liu; D A Estell; J V Miller; A Yaffe; D G Kleid; A D Levinson; H Oppermann
Journal:  Nucleic Acids Res       Date:  1983-05-11       Impact factor: 16.971

8.  Comparison of the immunogenicity, efficacy and safety of 10 micrograms and 20 micrograms of a hepatitis B vaccine: a prospective randomized trial.

Authors:  E K Yeoh; C L Lai; W K Chang; H Y Lo
Journal:  J Hyg (Lond)       Date:  1986-06

9.  Hepatitis B vaccine: prospects for duration of immunity.

Authors:  S Krugman; M Davidson
Journal:  Yale J Biol Med       Date:  1987 Jul-Aug

Review 10.  Hepatitis virus vaccines: present status.

Authors:  S Krugman
Journal:  Yale J Biol Med       Date:  1982 May-Aug
  10 in total

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