Pesticide induced changes in the mouse hepatic microsomal cytochrome P-450-dependent monooxygenase system and other enzymes.

Livers of mice previously treated with potential inducers were tested for effects on the microsomal cytochrome P-450-dependent monooxygenase system (including its constituent electron transport enzymes) and other enzymes. Microsomes were also examined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Pesticides, including chlorinated hydrocarbons, organophosphates, a carbamate, and an insecticide synergistic were tested for induction along with the well known inducers, phenobarbital and 3-methylcholanthrene. The results indicate that the pesticide inducers tested are of the phenobarbital type.