Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Ly-6 region regulates expression of multiple allospecificities.

Literature DB >> 7298087

Ly-6 region regulates expression of multiple allospecificities.

Abstract

The relationship between two alloantigens on mouse lymphocytes, that is Ly-6.2 and H9/25, which have previously been shown to have identical strain distribution patterns, was further investigated. Analysis of 39 (AKR x CBA) x CBA backcross progeny showed no segregation between these two antigens, indicating a close genetic linkage between them. Serological analysis showed that Ly-6.2 and H9/25 are differentially expressed on T-cell hybrid lines. Furthermore, cross-absorption of anti-Ly-6.2 serum with two cell lines revealed a heterogeneity among Ly-6 specificities. Semipurified H9/25 antigen failed to block anti-Ly-6.2 serum while anti-Ly-6.2 serum did not significantly block monoclonal antibody H9/25. These results suggest the presence of multiple allospecificities encoded for by the Ly-6 region.

Entities: Gene Species

Mesh：

Substances：
Antigens, Ly
Isoantigens

Year: 1981 PMID： 7298087 DOI： 10.1007/bf00346024

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

11 in total

1. Serological properties of anti-Ly-6.2 serum produced by a new immunization schedule.

Authors: M A Horton; P C Beverley; E Simpson
Journal: Immunogenetics Date: 1978-12 Impact factor: 2.846

2. An Ly-like specificity with extensive nonlymphoid expression.

Authors: P F Halloran; D Dutton; H Chance; Z Cohen
Journal: Immunogenetics Date: 1978-12 Impact factor: 2.846

3. Ly-6 is a T-cell differentiation antigen.

Authors: J N Woody
Journal: Nature Date: 1977-09-01 Impact factor: 49.962

4. Identification of Ia glycoproteins in rat thymus and purification from rat spleen.

Authors: W R McMaster; A F Williams
Journal: Eur J Immunol Date: 1979-06 Impact factor: 5.532

5. Genetic studies and effect on skin allograft survival of DBA-2 DAG, Ly, and M-locus antigens.

Authors: J A Sachs; B Huber; J Peña-Martinez; H Festenstein
Journal: Transplant Proc Date: 1973-12 Impact factor: 1.066

6. Fusion of T and B cells.

Authors: G Köhler; T Pearson; C Milstein
Journal: Somatic Cell Genet Date: 1977-05

7. Monoclonal antibody H9/25 reacts with functional subsets of T and B cells: killer, killer precursor and plaque-forming cells.

Authors: F Takei; H Waldmann; E S Lennox; C Milstein
Journal: Eur J Immunol Date: 1980-07 Impact factor: 5.532

8. Monoclonal antibodies to ThB detect close linkage of Ly-6 and a gene regulating ThB expression.

Authors: L A Eckhardt; L A Herzenberg
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

9. H 9/25 monoclonal antibody recognizes a new allospecificity of mouse lymphocyte subpopulations: strain and tissue distribution.

Authors: F Takei; G Galfrè; T Alderson; E S Lennox; C Milstein
Journal: Eur J Immunol Date: 1980-04 Impact factor: 5.532

Ly-6 region regulates expression of multiple allospecificities.

1. Serological properties of anti-Ly-6.2 serum produced by a new immunization schedule.

2. An Ly-like specificity with extensive nonlymphoid expression.

3. Ly-6 is a T-cell differentiation antigen.

4. Identification of Ia glycoproteins in rat thymus and purification from rat spleen.

5. Genetic studies and effect on skin allograft survival of DBA-2 DAG, Ly, and M-locus antigens.

6. Fusion of T and B cells.

7. Monoclonal antibody H9/25 reacts with functional subsets of T and B cells: killer, killer precursor and plaque-forming cells.

8. Monoclonal antibodies to ThB detect close linkage of Ly-6 and a gene regulating ThB expression.

9. H 9/25 monoclonal antibody recognizes a new allospecificity of mouse lymphocyte subpopulations: strain and tissue distribution.

10. Ala-1: murine alloantigen of activated lymphocytes. II. T and B effector cells express ala-1.

1. Biochemical characterization of H9/25, an allospecificity encoded by the Ly-6 region.

2. Genetic basis for Ly-6- defect: complementation between Ly-6- and Thy-1- mutant cell lines.

3. Studies of the mouse Ly-6 alloantigen system. II. Complexities of the Ly-6 region.

4. Ly-6A.2 and Ly-6E.1 molecules are antithetical and identical to MALA-1.