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Literature DB >> 729720

Endothelial injury by nicotine and its prevention.

Abstract

Nicotine administered i.v. or p.o. in doses above 0.0125 mg/kg to the rat caused a highly significant increase in circulating anuclear carcasses of endothelial cells estimated by an original method. This effect of nicotine was completely prevented by a prior oral administration of the flavonoids hydroxyethylrutosides (HR) or Mono-7-HR.

Entities: Chemical Species

Mesh：

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Year: 1978 PMID： 729720 DOI： 10.1007/bf02034689

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

1 in total

1. Vasotropic drugs--a survey based on a unifying concept of their mechanism of action.

Authors: J Hladovec
Journal: Arzneimittelforschung Date: 1977

1 in total

8 in total

1. Stabilization of endothelial lining and decrease in circulating endothelial cells--one mechanism underlying the clinical action of PGE1?

Authors: H Sinzinger; I Virgolini; P Fitscha; F Rauscha; J Kaliman
Journal: Br J Clin Pharmacol Date: 1988-06 Impact factor: 4.335

2. Beneficial effect of PGI2 on circulating endothelial cells.

Authors: H Sinzinger; F Rauscha; P Fitscha; J Kaliman
Journal: Basic Res Cardiol Date: 1988 Nov-Dec Impact factor: 17.165

3. Exercise training restores impaired dilator responses of cerebral arterioles during chronic exposure to nicotine.

Authors: William G Mayhan; Denise M Arrick; Hong Sun; Kaushik P Patel
Journal: J Appl Physiol (1985) Date: 2010-08-12

Review 4. Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders.

Authors: A N Wadworth; D Faulds
Journal: Drugs Date: 1992-12 Impact factor: 9.546

Endothelial injury by nicotine and its prevention.

1. Vasotropic drugs--a survey based on a unifying concept of their mechanism of action.

1. Stabilization of endothelial lining and decrease in circulating endothelial cells--one mechanism underlying the clinical action of PGE1?

2. Beneficial effect of PGI2 on circulating endothelial cells.

3. Exercise training restores impaired dilator responses of cerebral arterioles during chronic exposure to nicotine.

Review 4. Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders.

5. Effects of chronic oral consumption of nicotine on the rabbit aortic endothelium.

6. Nitric oxide synthase-dependent responses of the basilar artery during acute infusion of nicotine.

Review 7. Tobacco Use: A Major Risk Factor of Intracerebral Hemorrhage.

Review 8. Effects of cigarette smoking on metabolic events in the lung.