Literature DB >> 7296769

The formation of N-nitrosomethyl(2-oxopropyl)amine from N-nitrosobis(2-oxopropyl)amine in vivo.

T A Lawson, A S Helgeson, C J Grandjean, L Wallcave, D Nagel.   

Abstract

After injection of N-nitrosobis(2-oxopropyl)amine (BOP) (10 mg/kg) to male Syrian golden hamsters there were there concentrations of BOP and many of its metabolites in the hamster pancreas compared with the liver and salivary gland. Also, a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine, was found in both tissues.

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Year:  1981        PMID： 7296769     DOI： 10.1093/carcin/2.9.845

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  5 in total

Review 1.  The activation of beta-substituted nitrosamines that are carcinogenic to the pancreas.

Authors:  T Lawson; D Nagel; D Rogers
Journal:  Int J Pancreatol       Date:  1991-09

2.  Metabolism of the hamster pancreatic carcinogen methyl-2-oxopropylnitrosamine by hamster liver and pancreas.

Authors:  S C Chen; X Wang; L Zhou; C Kolar; T A Lawson; S S Mirvish
Journal:  Int J Pancreatol       Date:  2000-04

3.  Carcinogenesis in F-344 rats by nitrosobis(2-oxopropyl)amine and related compounds administered in drinking water.

Authors:  W Lijinsky; J E Saavedra; M D Reuber
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

4.  The activation of 3H-labeled N-nitrosobis(2-oxopropyl)amine by isolated hamster pancreas cells.

Authors:  T Lawson; C Kolar; R Garrels; E Kirchmann; D Nagel
Journal:  J Cancer Res Clin Oncol       Date:  1989       Impact factor: 4.553

Review 5.  Studies of pancreatic carcinogenesis in different animal models.

Authors:  D G Scarpelli; M S Rao; J K Reddy
Journal:  Environ Health Perspect       Date:  1984-06       Impact factor: 9.031
  5 in total

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