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Literature DB >> 7296659

Autoradiographic localization of 3H-GABA uptake in the thyroid gland of the rat.

Abstract

The uptake of gamma-aminobutyric acid (GABA) in the thyroid gland of the rat was studied autoradiographically following in vitro incubation. High-affinity GABA uptake was localized in follicle cells, whereas C cells (parafollicular cells) in general did not accumulate GABA by high-affinity transport. The follicle cells were also the main sites of low-affinity GABA uptake. Additionally, some nerve fibres were found to accumulate GABA. The predominant localization of GABA uptake in follicle cells is discussed in view of a presumed role of GABA in thyroid function.

Entities: Chemical Species

Mesh：

Substances：
gamma-Aminobutyric Acid

Year: 1981 PMID： 7296659 DOI： 10.1007/bf00210468

Source DB: PubMed Journal: Cell Tissue Res ISSN： 0302-766X Impact factor: 5.249

21 in total

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Journal: Biochem Pharmacol Date: 1975-05-01 Impact factor: 5.858

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Journal: J Biol Chem Date: 1964-10 Impact factor: 5.157

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Journal: Biochem Pharmacol Date: 1965-03 Impact factor: 5.858

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Authors: Y Friedman; M Lang; G Burke
Journal: Endocrinology Date: 1977-09 Impact factor: 4.736

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Authors: S Van Noorden; J M Polak; A G Pearse
Journal: Histochemistry Date: 1977-08-22

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Authors: A Melander; E Nilsson; F Sundler
Journal: Endocrinology Date: 1972-01 Impact factor: 4.736

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Authors: N G Bowery; D A Brown
Journal: Nat New Biol Date: 1972-07-19

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Authors: A J Patel; R Balázs; D Richter
Journal: Nature Date: 1970-06-20 Impact factor: 49.962

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Authors: M Hammerman; B Sacktor
Journal: Biochim Biophys Acta Date: 1978-05-18

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Authors: H Gebauer
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1981-08 Impact factor: 3.000

7 in total

Review 1. Polyspecificity of autoimmune responses in type 1 (autoimmune) diabetes.

Authors: L M Esteban; A G Baxter
Journal: Clin Exp Immunol Date: 2001-11 Impact factor: 4.330

2. Specific GABA binding in the adrenals and blood corticosteroid levels in stress in intact rats and rats with changes in the functional activity of the hypothalamo-pituitary-adrenal system.

Authors: T M Mishunina; V Ya Kononenko
Journal: Neurosci Behav Physiol Date: 2002 Mar-Apr