Literature DB >> 7296298

Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats.

V Kayser, G Guilbaud.   

Abstract

The effects of various i.v. naloxone doses (10 microgram, 300 microgram, 600 microgram, 1 mg/kg) were studied upon vocalization threshold to foot-pressure in 30 normal rats and 70 rats with Freund's adjuvant-induced arthritis. In arthritic rats, the lowest naloxone doses yielded a clear increase in pressure required to trigger vocalization (i.e. were analgesic) while the highest dose (1 mg/kg) was hyperalgesic. In normal rats, naloxone never induced significant changes in the vocalization threshold.

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Year:  1981        PMID： 7296298     DOI： 10.1016/0006-8993(81)91110-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  13 in total

1.  Modifications of the opioid system reactivity in Freund's adjuvant induced-arthritic and carrageenin-injected rats, models or chronic and acute inflammatory pain: behavioural and electrophysiological studies.

Authors:  V Kayser; G Guilbaud; J M Benoist
Journal:  Agents Actions       Date:  1988-02

2.  Agonist-antagonist combinations in opioid dependence: a translational approach.

Authors:  P Mannelli
Journal:  Dipend Patologiche       Date:  2010

3.  Potentiation of pentazocine analgesia by low-dose naloxone.

Authors:  J D Levine; N C Gordon; Y O Taiwo; T J Coderre
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

4.  Sensory receptors in ankle joint capsules of normal and arthritic rats.

Authors:  G Guilbaud; A Iggo; R Tegnér
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972

5.  Nociceptive flexion reflex and pain rating responses during endogenous opiate blockade with naltrexone in healthy young adults.

Authors:  Christopher R France; Mustafa al'Absi; Christopher Ring; Janis L France; Angie Harju; Lorentz E Wittmers
Journal:  Biol Psychol       Date:  2006-12-27       Impact factor: 3.251

Review 6.  Spinal opioid systems in inflammation.

Authors:  L Stanfa; A Dickenson
Journal:  Inflamm Res       Date:  1995-06       Impact factor: 4.575

7.  Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia.

Authors:  Mary M Lunzer; Ajay Yekkirala; Robert P Hebbel; Philip S Portoghese
Journal:  Proc Natl Acad Sci U S A       Date:  2007-03-26       Impact factor: 11.205

8.  Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment.

Authors:  S M Crain; K F Shen
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

9.  Standardization of the rat paw formalin test for the evaluation of analgesics.

Authors:  H Wheeler-Aceto; A Cowan
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

10.  Investigation into atropine-induced antinociception.

Authors:  C Ghelardini; P Malmberg-Aiello; A Giotti; M Malcangio; A Bartolini
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739
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