Literature DB >> 7296160

Rapid reversal by naloxone of the chronic effects of morphine on rat liver and brain tryptophan metabolism.

A A Badawy, M Evans.   

Abstract

The chronic morphine-induced inhibition of rat liver tryptophan pyrrolase activity and the resultant increases in tryptophan availability to the brain and brain 5-hydroxytryptamine (5-HT) synthesis are reversed within 10 min after naloxone administration. The possible involvement of hepatic tryptophan metabolism in morphine dependence is briefly discussed.

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Year:  1981        PMID： 7296160      PMCID： PMC2071748          DOI： 10.1111/j.1476-5381.1981.tb10457.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  The effects of ethanol on tryptophan pyrrolase activity and their comparison with those of phenobarbitone and morphine.

Authors:  A A Badawy; M Evans
Journal:  Adv Exp Med Biol       Date:  1975       Impact factor: 2.622

2.  The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.

Authors:  A A Badawy; M Evans
Journal:  Biochem J       Date:  1975-06       Impact factor: 3.857

3.  Role of serotonin in morphine effects.

Authors:  E L Way
Journal:  Fed Proc       Date:  1972 Jan-Feb

4.  The role of liver tryptophan pyrrolase in the opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on rat brain tryptophan metabolism.

Authors:  A A Badawy; N F Punjani; M Evans
Journal:  Biochem J       Date:  1981-04-15       Impact factor: 3.857

5.  Brain 5-hydroxytryptamine and cyclic AMP in morphine tolerance and dependence.

Authors:  E L Way; I K Ho; H H Loh
Journal:  Adv Biochem Psychopharmacol       Date:  1974

6.  Tryptophan catabolism by tryptophan pyrrolase in rat liver. The effect of tryptophan loads and changes in tryptophan pyrrolase activity.

Authors:  S N Young; T L Sourkes
Journal:  J Biol Chem       Date:  1975-07-10       Impact factor: 5.157

7.  Enhancement of rat brain tryptophan metabolism by chronic ethanol administration and possible involvement of decreased liver tryptophan pyrrolase activity.

Authors:  A A Badawy; N F Punjani; M Evans
Journal:  Biochem J       Date:  1979-03-15       Impact factor: 3.857

8.  Reversal by naloxone of the effects of chronic administration of drugs of dependence on rat liver and brain tryptophan metabolism.

Authors:  A A Badawy; M Evans; N F Punjani
Journal:  Br J Pharmacol       Date:  1981-10       Impact factor: 8.739
  8 in total

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