| Literature DB >> 7295759 |
R E Jones, E W Askew, A L Hecker, F D Hofeldt.
Abstract
The effects of salicylic acid on palmitic acid oxidation were studied using rat skeletal muscle mitochondria. Salicylic acid, in concentrations that exerted no effect on mitochondrial coupling (0.1 mM), significantly stimulated mitochondrial palmitic acid oxidation, with maximal stimulation occurring at subsaturating concentrations of substrate. In the same preparation, salicylate had no effect on the oxidation of palmitoylcarnitine or palmitoyl-CoA. Salicylate appears to augment the initial step of palmitic acid oxidation by lowering the apparent Michaelis constant (Km) of long chain fatty acid: CoASH ligase (AMP) (EC 6.2.1.3) for palmitic acid.Entities:
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Year: 1981 PMID： 7295759 DOI： 10.1016/0005-2760(81)90097-7
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002