Literature DB >> 7295757

The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA.

J Bremer.   

Abstract

The effect of fasting on palmitoyl-CoA: carnitine palmitoyltransferase (EC 2.3.1.21) in rat liver mitochondria and its inhibition by malonyl-CoA has been investigated. The activity of the outer carnitine palmitoyltransferase (transferase I) is nearly doubled after 24 h fasting, while the activity of total carnitine palmitoyltransferase (transferase I + II) increases only about 25%. The inhibition of the increased outer transferase by malonyl-CoA is decreased in fasting rats. The results suggest that carnitine palmitoyltransferase less sensitive to malonyl-CoA is exposed on the outer surface of the inner mitochondrial membrane in fasting, thus reducing the latency of the enzyme.

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Year:  1981        PMID： 7295757     DOI： 10.1016/0005-2760(81)90282-4

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  71 in total

1.  Turnover of carnitine palmitoyltransferase mRNA and protein in H4IIE cells. Effect of cyclic AMP and insulin.

Authors:  L Wang; P S Brady; L J Brady
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

2.  Effects of norepinephrine on the metabolism of fatty acids with different chain lengths in the perfused rat liver.

Authors:  E L Ishii-Iwamoto; M L Ferrarese; J Constantin; C Salgueiro-Pagadigorria; A Bracht
Journal:  Mol Cell Biochem       Date:  2000-02       Impact factor: 3.396

3.  Evidence that the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA is an important site of regulation of hepatic fatty acid oxidation in the fetal and newborn rabbit. Perinatal development and effects of pancreatic hormones in cultured rabbit hepatocytes.

Authors:  C Prip-Buus; J P Pegorier; P H Duee; C Kohl; J Girard
Journal:  Biochem J       Date:  1990-07-15       Impact factor: 3.857

4.  Interacting effects of L-carnitine and malonyl-CoA on rat liver carnitine palmitoyltransferase.

Authors:  M I Bird; E D Saggerson
Journal:  Biochem J       Date:  1985-08-15       Impact factor: 3.857

5.  Altered release of carnitine palmitoyltransferase activity by digitonin from liver mitochondria of rats in different physiological states.

Authors:  V A Zammit; C G Corstorphine
Journal:  Biochem J       Date:  1985-09-01       Impact factor: 3.857

6.  Effect of dietary n-3 and n-6 polyunsaturated fatty acids on lipid-metabolizing enzymes in obese rat liver.

Authors:  I Niot; J Gresti; J Boichot; G Semporé; G Durand; J Bézard; P Clouet
Journal:  Lipids       Date:  1994-07       Impact factor: 1.880

7.  Peroxisomal beta-oxidation from endogenous substrates. Demonstration through H2O2 production in the unanaesthetized mouse.

Authors:  C Van den Branden; I Kerckaert; F Roels
Journal:  Biochem J       Date:  1984-03-15       Impact factor: 3.857

8.  Carnitine palmitoyltransferase in liver and five extrahepatic tissues in the rat. Inhibition by DL-2-bromopalmitoyl-CoA and effect of hypothyroidism.

Authors:  E D Saggerson; C A Carpenter
Journal:  Biochem J       Date:  1986-05-15       Impact factor: 3.857

9.  Cholate extracts of mitochondrial outer membranes increase inhibition by malonyl-CoA of carnitine palmitoyltransferase-I by a mechanism involving phospholipids.

Authors:  R L Mynatt; J J Greenhaw; G A Cook
Journal:  Biochem J       Date:  1994-05-01       Impact factor: 3.857

10.  The hypotriglyceridemic effect of dietary n-3 FA is associated with increased beta-oxidation and reduced leptin expression.

Authors:  J Ukropec; J E Reseland; D Gasperikova; E Demcakova; L Madsen; R K Berge; A C Rustan; I Klimes; C A Drevon; E Sebökova
Journal:  Lipids       Date:  2003-10       Impact factor: 1.880
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