Literature DB >> 7294

NADP+ and NADPH in glucose-6-phosphate dehydrogenase-deficient erythrocytes under oxidative stimulation.

C Mareni, G F Gaetani.   

Abstract

A mild oxidative stimulation of the hexose monophosphate pathway of human glucose-6-phosphate dehydrogenase (EC 1.1.1.49)-deficient erythrocytes (Mediterranean variant) causes a significant drop in NADPH. These results, other than to confirm that glucose-6-phosphate dehydrogenase deficiency is a product deficiency disorder, demonstrate that under oxidative stimulation glutathione reductase may become functionally impaired and GSSG cannot be reduced at a sufficient rate.

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Year:  1976        PMID： 7294     DOI： 10.1016/0005-2728(76)90014-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  2 in total

1.  Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress.

Authors:  H Juhnke; B Krems; P Kötter; K D Entian
Journal:  Mol Gen Genet       Date:  1996-09-25

2.  Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress.

Authors:  Stefania Filosa; Annalisa Fico; Francesca Paglialunga; Marco Balestrieri; Almudena Crooke; Pasquale Verde; Paolo Abrescia; José M Bautista; Giuseppe Martini
Journal:  Biochem J       Date:  2003-03-15       Impact factor: 3.857
  2 in total

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