Literature DB >> 7292523

Decreased copper content in rat kidney metallothionein and its relation to acute cadmium nephropathy.

K T Suzuki, M Yamamura, Y K Yamada, F Shimizu.   

Abstract

Repeated s.c. injections of cadmium chloride into rats (3 mg Cd/kg body weight, 4 times a week) caused acute and transitory tubular necrosis after 2 to 3 weeks; recovery was observed after 4 weeks despite continued loading. Kidney copper decreased for the first 3 weeks and was slightly increased after 4 weeks. Distribution profiles of cadmium (Cd), zinc (Zn), copper (Cu) on an SW column revealed that elution profiles of kidney metallothionein changed from typical kidney with high copper content to typical liver metallothioneins with tubular necrosis and restoration.

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Year:  1980        PMID： 7292523     DOI： 10.1016/0378-4274(80)90046-6

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  6 in total

1.  Effect of chronic cadmium administration on liver and kidney concentrations of zinc, copper, iron, manganese, and chromium.

Authors:  J K Friel; R F Borgman; R K Chandra
Journal:  Bull Environ Contam Toxicol       Date:  1987-04       Impact factor: 2.151

2.  Effect of diet on tissue retention of cadmium heavily preaccumulated in rats.

Authors:  K T Suzuki; Y Tanaka; E Miyamoto; R Kawamura; M Nishikawa; Y K Yamada; M Yamamura
Journal:  Arch Environ Contam Toxicol       Date:  1984-09       Impact factor: 2.804

3.  Effect of zinc deficiency on the accumulation of metallothionein and cadmium in the rat liver and kidney.

Authors:  M Sato; Y Nagai
Journal:  Arch Environ Contam Toxicol       Date:  1989 Jul-Aug       Impact factor: 2.804

4.  Metal-dependent properties of metallothionein. Replacement in vitro of zinc in zinc-thionein with copper.

Authors:  K T Suzuki; T Maitani
Journal:  Biochem J       Date:  1981-11-01       Impact factor: 3.857

5.  Interaction of alkylmercuric compounds with sodium selenite. III. Biotransformation, levels of metallothioneinlike proteins and endogenous copper in some tissues of rats exposed to methyl or ethylmercuric chloride with and without sodium selenite.

Authors:  E A Brzeźnicka; J Chmielnicka
Journal:  Environ Health Perspect       Date:  1985-05       Impact factor: 9.031

6.  Studies of cadmium uptake and metabolism by the kidney.

Authors:  K T Suzuki
Journal:  Environ Health Perspect       Date:  1984-03       Impact factor: 9.031
  6 in total

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