Literature DB >> 7292514

Effect of styrene on levels of serotonin, noradrenaline, dopamine and activity of acetyl cholinesterase and monoamine oxidase in rat brain.

R Husain, S P Srivastava, M Mushtaq, P K Seth.   

Abstract

Oral intubation of styrene (1 ml/kg body weight daily) in adult male albino rats for 15 days produced a significant increase in serotonin and noradrenaline but no change in dopamine contents in brain. The brain of treated animals also showed a significant decrease in monoamine oxidase (MAO) but no change in acetyl cholinesterase (AChE) activity. The neurotoxic effects of styrene may be mediated through alterations in levels of these biogenic amines in the brain tissue.

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Year:  1980        PMID： 7292514     DOI： 10.1016/0378-4274(80)90084-3

Source DB:  PubMed          Journal:  Toxicol Lett        ISSN： 0378-4274            Impact factor:   4.372


  8 in total

1.  Effect of styrene oxide on levels of biogenic amines and activity of monoamine oxidase in different parts of rat brain.

Authors:  R Husain; N F Zaidi; S P Srivastava; P K Seth
Journal:  Bull Environ Contam Toxicol       Date:  1985-05       Impact factor: 2.151

2.  Effect of styrene on dopamine receptors.

Authors:  A K Agrawal; S P Srivastava; P K Seth
Journal:  Bull Environ Contam Toxicol       Date:  1982-10       Impact factor: 2.151

3.  Some behavioral effects of early styrene intoxication in experimental animals.

Authors:  R Husain; S P Srivastava; P K Seth
Journal:  Arch Toxicol       Date:  1985-04       Impact factor: 5.153

4.  Peripheral markers of neurochemical function among workers exposed to styrene.

Authors:  H Checkoway; L G Costa; J Camp; T Coccini; W E Daniell; R L Dills
Journal:  Br J Ind Med       Date:  1992-08

5.  Regional alterations of brain catecholamines by styrene exposure in rabbits.

Authors:  A Mutti; M Falzoi; A Romanelli; I Franchini
Journal:  Arch Toxicol       Date:  1984-09       Impact factor: 5.153

6.  Methyl methacrylate induced behavioural and neurochemical changes in rats.

Authors:  R Husain; S P Srivastava; P K Seth
Journal:  Arch Toxicol       Date:  1985-10       Impact factor: 5.153

Review 7.  Biomarker research in neurotoxicology: the role of mechanistic studies to bridge the gap between the laboratory and epidemiological investigations.

Authors:  L G Costa
Journal:  Environ Health Perspect       Date:  1996-03       Impact factor: 9.031

8.  Effects of Styrene-metabolizing Enzyme Polymorphisms and Lifestyle Behaviors on Blood Styrene and Urinary Metabolite Levels in Workers Chronically Exposed to Styrene.

Authors:  Ki-Woong Kim
Journal:  Toxicol Res       Date:  2015-12
  8 in total

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