Literature DB >> 7291992

Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine.

M Pollard, P H Luckert.   

Abstract

Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.

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Year:  1981        PMID： 7291992     DOI： 10.1126/science.7291992

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  23 in total

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