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Literature DB >> 7288436

Acathisia-syndrome: involvement of noradrenergic mechanisms.

M Bartels, H J Gaertner, G Golfinopoulos.

Abstract

The involvement of noradrenergic mechanisms in patients suffering from acathisia was investigated by determination of urinary night-time 3-methoxy-4-hydroxy-phenyl glycol (MHPG)-excretion and was compared both with control patients matched according to age and sex and healthy individuals. A significantly reduced MHPG excretion was found among the acathisia patients. It is suggested that a supersensitivity of the spinal noradrenergically innervated receptors caused by their long-term blocking is responsible for occurrence of the symptoms.

Entities: Chemical Disease Species

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Year: 1981 PMID： 7288436 DOI： 10.1007/BF01253094

Source DB: PubMed Journal: J Neural Transm Impact factor: 3.575

8 in total

1. A pharmacologic study of the stiff-man syndrome. Correlation of clinical symptoms with urinary 3-methoxy-4-hydroxy-phenyl glycol excretion.

Authors: R T Schmidt; S M Stahl; R Spehlmann
Journal: Neurology Date: 1975-07 Impact factor: 9.910

7. 4-methoxy-3-hydroxyphenylglycol as an internal standard for the determination of 3-methoxy-4-hydroxyphenyglycol in urine: results obtained in depressed patients and healthy controls.

Authors: H J Gaertner; G Wiatr; H J Kuss
Journal: J Clin Chem Clin Biochem Date: 1980-09

8. 3-Methoxy-4-hydroxyphenethyleneglycol production by human brain in vivo.

Authors: J W Maas; S E Hattox; N M Greene; D H Landis
Journal: Science Date: 1979-09-07 Impact factor: 47.728

8 in total

1 in total

1. Benzodiazepines in psychotic States.

Authors: J Ananth; O Solano
Journal: Indian J Psychiatry Date: 1993-04 Impact factor: 1.759

1 in total

Acathisia-syndrome: involvement of noradrenergic mechanisms.

1. A pharmacologic study of the stiff-man syndrome. Correlation of clinical symptoms with urinary 3-methoxy-4-hydroxy-phenyl glycol excretion.

2. The development of supersensitivity to norepinephrine after pretreatment with reserpine.

3. Effect of chlorpromazine treatment on monoamine metabolite levels in cerebrospinal fluid of psychotic patients.

4. An improved procedure of 3-methoxy-4-hydroxyphenyl-ethylene glycol determination by gas-liquid chromatography.

5. Why do schizophrenic patients refuse to take their drugs?

6. Tricyclic-induced mania and MHPG excretion.

7. 4-methoxy-3-hydroxyphenylglycol as an internal standard for the determination of 3-methoxy-4-hydroxyphenyglycol in urine: results obtained in depressed patients and healthy controls.

8. 3-Methoxy-4-hydroxyphenethyleneglycol production by human brain in vivo.

1. Benzodiazepines in psychotic States.