| Literature DB >> 7288294 |
Abstract
A simplified procedure for the synthesis of short acyl chain phosphatidylcholines is described. A mixed fatty acid-trifluoroacetic anhydride is used to acylate sn-glycero-3-phosphocholine (GPC) which has been dissolved in trifluoroacetic acid. Yields exceeding 70% are achieved in 30-min reaction time using 1.5 to 2.0 equivalents of mixed anhydride per, GPC hydroxyl. This allows a more economical use of labeled short chain acids.Entities:
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Year: 1981 PMID: 7288294
Source DB: PubMed Journal: J Lipid Res ISSN: 0022-2275 Impact factor: 5.922