Literature DB >> 7288292

Sterol synthesis. A simplified method for the synthesis of 32-oxygenated derivatives of 24,25-dihydrolanosterol.

E J Parish, G J Schroepfer.   

Abstract

A simplified method is described for the preparation of 14 alpha-hydroxymethyl-4,4-dimethyl-5 alpha-cholest-8-en-e beta-ol, 14 alpha-hydroxymethyl-4,4-dimethyl-5 alpha-cholest-7-en-3 beta-ol, and 14 alpha-hydroxymethyl-4,4-dimethyl-5-alpha-cholest-6-en-3 beta-ol from commercial lanosterol. This method represents a modification of the approach introduced by Fried and co-workers (Fried, J., J. W. Brown, and L. Borkenhagen. 1965. Tetrahedron Lett. 2499-2504).

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Year:  1981        PMID： 7288292

Source DB:  PubMed          Journal:  J Lipid Res        ISSN： 0022-2275            Impact factor:   5.922


  6 in total

1.  Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol.

Authors:  Tatiana Y Hargrove; Zdzislaw Wawrzak; Jialin Liu; Michael R Waterman; W David Nes; Galina I Lepesheva
Journal:  J Lipid Res       Date:  2011-11-30       Impact factor: 5.922

2.  Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives.

Authors:  Debora F Vieira; Jun Yong Choi; William R Roush; Larissa M Podust
Journal:  Chembiochem       Date:  2014-04-25       Impact factor: 3.164

3.  Pneumocysterol [(24Z)-ethylidenelanost-8-en-3beta-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii hominis: structural identity and chemical synthesis.

Authors:  E S Kaneshiro; Z Amit; M M Swonger; G P Kreishman; E E Brooks; M Kreishman; K Jayasimhulu; E J Parish; H Sun; S A Kizito; D H Beach
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-05       Impact factor: 11.205

4.  Oxysterols: chemical synthesis, biosynthesis and biological activities.

Authors:  E J Parish; V B Nanduri; H H Kohl; F R Taylor
Journal:  Lipids       Date:  1986-01       Impact factor: 1.880

Review 5.  Drug strategies targeting CYP51 in neglected tropical diseases.

Authors:  Jun Yong Choi; Larissa M Podust; William R Roush
Journal:  Chem Rev       Date:  2014-10-22       Impact factor: 60.622

Review 6.  Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors.

Authors:  David J Leaver
Journal:  Molecules       Date:  2018-07-17       Impact factor: 4.411
  6 in total

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