Literature DB >> 7287302

Identification of dermorphin and Hyp6-dermorphin in skin extracts of the Brazilian frog Phyllomedusa rhodei.

P C Montecucchi, R de Castiglione, V Erspamer.   

Abstract

Methanol extracts of the skin of the Brazilian frog Phyllomedusa rhodei contain approximately equal amounts of dermorphin and its analogue Hyp6-dermorphin, two opiate-like heptapeptides. A unique feature of their sequence is the presence of a D-amino acid residue at position 2. Hyp6-dermorphin possesses a spectrum of central and peripheral bioactivity very similar to that of dermorphin.

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Year:  1981        PMID： 7287302     DOI： 10.1111/j.1399-3011.1981.tb01997.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN： 0367-8377


  12 in total

1.  Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.

Authors:  Kimitaka Shiotani; Tingyou Li; Anna Miyazaki; Yuko Tsuda; Sharon D Bryant; Akihiro Ambo; Yusuke Sasaki; Lawrence H Lazarus; Yoshio Okada
Journal:  Bioorg Med Chem Lett       Date:  2006-09-01       Impact factor: 2.823

2.  Antinociception and physical dependence produced by [D-Arg2] dermorphin tetrapeptide analogues and morphine in rats.

Authors:  K Chaki; S Kawamura; K Kisara; S Sakurada; T Sakurada; Y Sasaki; T Sato; K Susuki
Journal:  Br J Pharmacol       Date:  1988-09       Impact factor: 8.739

3.  Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain.

Authors:  Vinod Tiwari; Fei Yang; Shao-Qiu He; Ronen Shechter; Chen Zhang; Bin Shu; Tong Zhang; Vineeta Tiwari; Yun Wang; Xinzhong Dong; Yun Guan; Srinivasa N Raja
Journal:  Anesthesiology       Date:  2016-03       Impact factor: 7.892

4.  Dermorphin analogues containing D-kyotorphin: structure-antinociceptive relationships in mice.

Authors:  K Kisara; S Sakurada; T Sakurada; Y Sasaki; T Sato; K Suzuki; H Watanabe
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

5.  Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.

Authors:  Kimitaka Shiotani; Tingyou Li; Anna Miyazaki; Yuko Tsuda; Toshio Yokoi; Akihiro Ambo; Yusuke Sasaki; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Journal:  Bioorg Med Chem Lett       Date:  2007-08-28       Impact factor: 2.823

6.  Pharmacological data on dermorphins, a new class of potent opioid peptides from amphibian skin.

Authors:  M Broccardo; V Erspamer; G Falconieri Erspamer; G Improta; G Linari; P Melchiorri; P C Montecucchi
Journal:  Br J Pharmacol       Date:  1981-07       Impact factor: 8.739

7.  Complete nucleotide sequence of mRNA for caerulein precursor from Xenopus skin: the mRNA contains an unusual repetitive structure.

Authors:  T Wakabayashi; H Kato; S Tachibana
Journal:  Nucleic Acids Res       Date:  1985-03-25       Impact factor: 16.971

8.  Dermorphin, a new opioid peptide, stimulates thyrotropin secretion in normal subjects.

Authors:  E Roti; E Degli Uberti; S Salvadori; M Bianconi; R Emanuele; C Rotola; G Trasforini; G Robuschi; R Tomatis; A Gnudi
Journal:  J Endocrinol Invest       Date:  1984-06       Impact factor: 4.256

9.  Prerequisite for His(4) in deltorphin A for highδ opioid receptor selectivity.

Authors:  S Salvadori; R Guerrini; V Forlani; S D Bryant; M Attila; L H Lazarus
Journal:  Amino Acids       Date:  1994-10       Impact factor: 3.520

Review 10.  Advancing d-amino acid-containing peptide discovery in the metazoan.

Authors:  David H Mast; James W Checco; Jonathan V Sweedler
Journal:  Biochim Biophys Acta Proteins Proteom       Date:  2020-09-28       Impact factor: 3.036
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