Literature DB >> 7287299

Amino acid composition and sequence of dermorphin, a novel opiate-like peptide from the skin of Phyllomedusa sauvagei.

P C Montecucchi, R de Castiglione, S Piani, L Gozzini, V Erspamer.   

Abstract

Dermorphin, a heptapeptide with very potent opiate-like activity, has been isolated from methanol extracts of the skin of the South American frog Phyllomedusa sauvagei. The amino acid sequence of the peptide is: H-Try-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2. Dermorphin presents striking differences from the known enkephalins; it offers a surprising example of a peptide from Vertebrata containing a D-amino acid residue in its sequence.

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Year:  1981        PMID： 7287299     DOI： 10.1111/j.1399-3011.1981.tb01993.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN： 0367-8377


  48 in total

1.  Analysis of Endogenous D-Amino Acid-Containing Peptides in Metazoa.

Authors:  Lu Bai; Sarah Sheeley; Jonathan V Sweedler
Journal:  Bioanal Rev       Date:  2009-12

2.  Synthesis of 3,6-bis[H-Tyr/H-Dmt-NH(CH2)m,n]-2(1H)pyrazinone derivatives: function of alkyl chain length on opioid activity.

Authors:  Kimitaka Shiotani; Tingyou Li; Anna Miyazaki; Yuko Tsuda; Sharon D Bryant; Akihiro Ambo; Yusuke Sasaki; Lawrence H Lazarus; Yoshio Okada
Journal:  Bioorg Med Chem Lett       Date:  2006-09-01       Impact factor: 2.823

3.  Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.

Authors:  Tom Willemse; Emilie Eiselt; Karlijn Hollanders; Wim Schepens; Herman W T van Vlijmen; Nga N Chung; Véronique Blais; Brain Holleran; Jean-Michel Longpré; Peter W Schiller; Bert U W Maes; Philippe Sarret; Louis Gendron; Steven Ballet
Journal:  Bioorg Med Chem Lett       Date:  2018-05-12       Impact factor: 2.823

4.  Chimeric opioid peptides: tools for identifying opioid receptor types.

Authors:  G X Xie; A Miyajima; T Yokota; K Arai; A Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

5.  Opioid activity of dermenkephalin analogues in the guinea-pig myenteric plexus and the hamster vas deferens.

Authors:  S Sagan; A D Corbett; M Amiche; A Delfour; P Nicolas; H W Kosterlitz
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

6.  Dermorphin analogues containing D-kyotorphin: structure-antinociceptive relationships in mice.

Authors:  K Kisara; S Sakurada; T Sakurada; Y Sasaki; T Sato; K Suzuki; H Watanabe
Journal:  Br J Pharmacol       Date:  1986-01       Impact factor: 8.739

7.  Biosynthesis of a D-amino acid in peptide linkage by an enzyme from frog skin secretions.

Authors:  Alexander Jilek; Christa Mollay; Christa Tippelt; Jacques Grassi; Giuseppina Mignogna; Johannes Müllegger; Veronika Sander; Christine Fehrer; Donatella Barra; Günther Kreil
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-09       Impact factor: 11.205

8.  cDNAs encoding [D-Ala2]deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides.

Authors:  K Richter; R Egger; L Negri; R Corsi; C Severini; G Kreil
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

9.  Design and synthesis of opioidmimetics containing 2',6'-dimethyl-L-tyrosine and a pyrazinone-ring platform.

Authors:  Kimitaka Shiotani; Tingyou Li; Anna Miyazaki; Yuko Tsuda; Toshio Yokoi; Akihiro Ambo; Yusuke Sasaki; Sharon D Bryant; Lawrence H Lazarus; Yoshio Okada
Journal:  Bioorg Med Chem Lett       Date:  2007-08-28       Impact factor: 2.823

10.  Dermorphin-related peptides from the skin of Phyllomedusa bicolor and their amidated analogs activate two mu opioid receptor subtypes that modulate antinociception and catalepsy in the rat.

Authors:  L Negri; G F Erspamer; C Severini; R L Potenza; P Melchiorri; V Erspamer
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205
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