Literature DB >> 7287180

Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant.

R I Lehrer, D Szklarek, M E Selsted, J Fleischmann.   

Abstract

We measured the microbicidal peptides MCP-1 and MCP-2 in rabbit alveolar macrophages (AM), comparing rabbits pretreated with complete Freund adjuvant with untreated control animals. Levels of MCP-1 increased from 4.7 +/- 0.6 microgram/10(7) resident AM to 13.2 +/- 0.1 microgram/10(7) complete Freund adjuvant-elicited AM. MCP-2 levels rose from 1.8 +/- 0.1 microgram/10(7) resident AM to 7.3 +/- 0.4 microgram/10(7) complete Freund adjuvant-elicited AM. The activities of five lysosomal hydrolases (beta-D-glucuronidase, beta-D-galactosidase, acid phosphatase, N-acetyl-beta-D-galactosaminidase, and N-acetyl-beta-D-glucosaminidase) were 44 to 96% higher in complete Freund adjuvant-elicited AM, and lysozyme activity was three- to fourfold higher. As MCP-1 and MCP-2 are major constituents of rabbit AM and exhibit potent antibacterial and antifungal properties, they may contribute to the expression of microbicidal activity in both resident and activated states.

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Year:  1981        PMID： 7287180      PMCID： PMC350777          DOI： 10.1128/iai.33.3.775-778.1981

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  18 in total

Review 1.  The pulmonary-alveolar macrophage (first of two parts).

Authors:  W G Hocking; D W Golde
Journal:  N Engl J Med       Date:  1979-09-13       Impact factor: 91.245

2.  Lysosomal enzymes of cultured fibroblasts of cystic fibrosis patients.

Authors:  J Butterworth; F Scott; W M McCrae; A D Bain
Journal:  Clin Chim Acta       Date:  1972-08       Impact factor: 3.786

3.  Radial diffusion in gel for micro determination of enzymes. I. Muramidase, alpha-amylase, DNase 1, RNase A, acid phosphatase, and alkaline phosphatase.

Authors:  W B Schill; G F Schumacher
Journal:  Anal Biochem       Date:  1972-04       Impact factor: 3.365

4.  Changes in morphology and in lysozyme content of free alveolar cells after the intravenous injection of killed BCG in oil.

Authors:  E S Leake; Q N Myrvik
Journal:  J Reticuloendothel Soc       Date:  1968-02

5.  4-Methylumbelliferyl phosphate as a substrate for lysosomal acid phosphatase.

Authors:  D Robinson; P Willcox
Journal:  Biochim Biophys Acta       Date:  1969-09-30

6.  Purification and properties of rabbit alveolar macrophage lysozyme.

Authors:  S F Carroll; R J Martinez
Journal:  Infect Immun       Date:  1979-05       Impact factor: 3.441

Review 7.  Defense mechanisms of the respiratory membrane.

Authors:  G M Green; G J Jakab; R B Low; G S Davis
Journal:  Am Rev Respir Dis       Date:  1977-03

Review 8.  Severe candidal infections: clinical perspective, immune defense mechanisms, and current concepts of therapy.

Authors:  J E Edwards; R I Lehrer; E R Stiehm; T J Fischer; L S Young
Journal:  Ann Intern Med       Date:  1978-07       Impact factor: 25.391

9.  Further biochemical and morphological studies of granule fractions from rabbit heterophil leukocytes.

Authors:  M Baggiolini; J G Hirsch; C De Duve
Journal:  J Cell Biol       Date:  1970-06       Impact factor: 10.539

10.  Lysosomal phospholipase A 1 and A 2 of normal and bacillus calmette guerin-induced alveolar macrophages.

Authors:  R C Franson; M Waite
Journal:  J Cell Biol       Date:  1973-03       Impact factor: 10.539
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  14 in total

Review 1.  Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells.

Authors:  T Ganz; A Oren; R I Lehrer
Journal:  Med Microbiol Immunol       Date:  1992       Impact factor: 3.402

2.  Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin.

Authors:  M E Selsted; S S Harwig
Journal:  Infect Immun       Date:  1987-09       Impact factor: 3.441

3.  Response of inbred mice to aerosol challenge with Mycobacterium tuberculosis.

Authors:  S A Musa; Y Kim; R Hashim; G Z Wang; C Dimmer; D W Smith
Journal:  Infect Immun       Date:  1987-08       Impact factor: 3.441

4.  Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes.

Authors:  R I Lehrer; K Daher; T Ganz; M E Selsted
Journal:  J Virol       Date:  1985-05       Impact factor: 5.103

5.  Salmonella infection increases porcine antibacterial peptide concentrations in serum.

Authors:  G Zhang; C R Ross; S S Dritz; J C Nietfeld; F Blecha
Journal:  Clin Diagn Lab Immunol       Date:  1997-11

6.  Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin.

Authors:  M A Couto; L Liu; R I Lehrer; T Ganz
Journal:  Infect Immun       Date:  1994-06       Impact factor: 3.441

7.  Heterogeneous activity of immature and mature cells of the murine monocyte-macrophage lineage derived from different anatomical districts against yeast-phase Candida albicans.

Authors:  T Decker; M L Lohmann-Matthes; M Baccarini
Journal:  Infect Immun       Date:  1986-11       Impact factor: 3.441

8.  Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages.

Authors:  R I Lehrer; M E Selsted; D Szklarek; J Fleischmann
Journal:  Infect Immun       Date:  1983-10       Impact factor: 3.441

9.  Isolation and characterization of human defensin cDNA clones.

Authors:  K A Daher; R I Lehrer; T Ganz; M Kronenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

10.  Inhibition of Chlamydia psittaci in oxidatively active thioglycolate-elicited macrophages: distinction between lymphokine-mediated oxygen-dependent and oxygen-independent macrophage activation.

Authors:  G I Byrne; C L Faubion
Journal:  Infect Immun       Date:  1983-05       Impact factor: 3.441
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