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Literature DB >> 7286060

Pharmacokinetic study of chloramphenicol in patients with liver disease.

A P Narang, D V Datta, N Nath, V S Mathur.

Abstract

The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t 1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under the time - concentrations curve (AUC) showed an increase. The t 1/2 of chloramphenicol showed a significant correlation with serum albumin and prothrombin time index.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Chloramphenicol

Year: 1981 PMID： 7286060 DOI： 10.1007/BF00542103

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

17 in total

1. Administration of chloromycetin to normal human subjects.

Authors: H L LEY; J E SMADEL; T T CROCKER
Journal: Proc Soc Exp Biol Med Date: 1948-05

2. Biochemical studies on chloramphenicol; colorimetric methods for the determination of chloramphenicol and related nitro compounds.

Authors: A J GLAZKO; L M WOLF; W A DILL
Journal: Arch Biochem Date: 1949-10

3. The 'grey toddler'. Chloramphenicol toxicity.

Authors: A W Craft; J T Brocklebank; E N Hey; R H Jackson
Journal: Arch Dis Child Date: 1974-03 Impact factor: 3.791

4. Elimination of chloramphenicol and thiamphenicol in subjects with cirrhosis of the liver.

Authors: F Azzollini; A Gazzaniga; E Lodola; R Natangelo
Journal: Int J Clin Pharmacol Date: 1972-06

5. Effect of protein depletion in guinea-pigs on glucuronate conjugation of chloramphenicol by liver microsomes.

Authors: J A Smith; T C Butler; D T Poole
Journal: Biochem Pharmacol Date: 1973-04-15 Impact factor: 5.858

6. Chloramphenicol-associated encephalopathy.

Authors: P H Levine; W Regelson; J F Holland
Journal: Clin Pharmacol Ther Date: 1970 Mar-Apr Impact factor: 6.875

Review 7. Non-cirrhotic portal fibrosis ('idiopathic' portal hypertension in India).

Authors: D V Datta
Journal: J Assoc Physicians India Date: 1976-08

8. Effect of chronic administration of centrally acting compounds on chloramphenicol metabolism in schizophrenic patients.

Authors: A Watanabe
Journal: Pharmacology Date: 1974 Impact factor: 2.547

9. Estimation of hepatic bilirubin UDP-glucuronyl transferase in patients with noncirrhotic portal fibrosis and liver disease: Significance and limitations.

Authors: D V Datta; R Nair; C R Nair
Journal: Am J Dig Dis Date: 1975-10

Pharmacokinetic study of chloramphenicol in patients with liver disease.

1. Administration of chloromycetin to normal human subjects.

2. Biochemical studies on chloramphenicol; colorimetric methods for the determination of chloramphenicol and related nitro compounds.

3. The 'grey toddler'. Chloramphenicol toxicity.

4. Elimination of chloramphenicol and thiamphenicol in subjects with cirrhosis of the liver.

5. Effect of protein depletion in guinea-pigs on glucuronate conjugation of chloramphenicol by liver microsomes.

6. Chloramphenicol-associated encephalopathy.

Review 7. Non-cirrhotic portal fibrosis ('idiopathic' portal hypertension in India).

8. Effect of chronic administration of centrally acting compounds on chloramphenicol metabolism in schizophrenic patients.

9. Estimation of hepatic bilirubin UDP-glucuronyl transferase in patients with noncirrhotic portal fibrosis and liver disease: Significance and limitations.

10. Chloramphenicol metabolism in children with protein-calorie malnutrition.

Review 1. Clinical pharmacokinetics in patients with liver disease.

Review 2. Guide to drug dosage in hepatic disease.

3. Detection of chloramphenicol residues in pigs with different agar diffusion methods.

4. Chloramphenicol clearance in typhoid fever: implications for therapy.

5. Relevance of Liver Failure for Anti-Infective Agents: From Pharmacokinetic Alterations to Dosage Adjustments.