Literature DB >> 7285487

Onset of peak impairment after diazepam and after alcohol.

E H Ellinwood, M Linnoila, M E Easler, D W Molter.   

Abstract

Single doses of diazepam induced peak impairment of performance on cognitive and psychomotor tasks early (20 min after ingestion), when blood levels had reached less than two thirds of their eventual plateau. Alcohol did not have this effect. Early peak impairment and the acute tolerance that follows it contribute greatly to the lack of correlation between diazepam plasma level and performance impairment.

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Year:  1981        PMID： 7285487     DOI： 10.1038/clpt.1981.199

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN： 0009-9236            Impact factor:   6.875


  8 in total

1.  Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. I: Lorazepam.

Authors:  S K Gupta; E H Ellinwood; A M Nikaido; D G Heatherly
Journal:  J Pharmacokinet Biopharm       Date:  1990-04

2.  The behavioral actions of diazepam and oxazepam are similar.

Authors:  S P Mewaldt; M M Ghoneim; J V Hinrichs
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

3.  Diazepam: prediction of pharmacodynamics from pharmacokinetics.

Authors:  E H Ellinwood; A Nikaido; D Heatherly
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

4.  Simultaneous modeling of the pharmacokinetic and pharmacodynamic properties of benzodiazepines. II. Triazolam.

Authors:  S K Gupta; E H Ellinwood; A M Nikaido; D G Heatherly
Journal:  Pharm Res       Date:  1990-06       Impact factor: 4.200

5.  An investigation into the interaction between ethanol at low doses and the benzodiazepines nitrazepam and temazepam on psychomotor performance in normal subjects.

Authors:  P V Taberner; C J Roberts; E Shrosbree; C J Pycock; L English
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

6.  Benzodiazepine pharmacodynamics: evidence for biophase rate limiting mechanisms.

Authors:  E H Ellinwood; A M Nikaido; D G Heatherly; T D Bjornsson
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

7.  Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction.

Authors:  P Dorian; E M Sellers; K L Reed; J J Warsh; C Hamilton; H L Kaplan; T Fan
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

8.  Effects of oxazepam on eye movements and performance in vigilance tasks with static and dynamic stimuli.

Authors:  T H van Leeuwen; M N Verbaten; H S Koelega; G Camfferman; J van der Gugten; J L Slangen
Journal:  Psychopharmacology (Berl)       Date:  1994-02       Impact factor: 4.530
  8 in total

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