| Literature DB >> 7285116 |
S L Martin, E A Zimmer, W S Davidson, A C Wilson, Y W Kan.
Abstract
We have sequenced the 3' and 5' untranslated regions of beta-globin mRNAs from cebus monkey, rhesus monkey and chimpanzee. A comparison with the corresponding human sequences reveals that the rate of sequence divergence among the higher primates is the same in the 3' and 5' noncoding regions and that this rate is several times lower than the rate for silent substitutions in the coding regions. In addition, the rate of sequence divergence in the 3' untranslated region of the primate beta-globin nRNA is several times lower than the rate calculated for this region from other comparisons. The low rate of sequence divergence in the noncoding 3' end of the primate beta-globin mRNAs may indicate a specialized and significant function for this region in the higher primates.Entities:
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Year: 1981 PMID： 7285116 DOI： 10.1016/0092-8674(81)90181-1
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582