Calcium uptake and retention during long-term potentiation of neuronal activity in the rat hippocampal slice preparation.

Alterations in 45Ca uptake and retention as well as total intracellular calcium content were measured in hippocampal 'in vitro' slice preparations following the induction of long-term potentiation (LTP) in CA1 pyramidal neurones. The results indicate that tetanic stimulation of the Schaffer-commissural input produces a significant increase in the uptake and retention of calcium which parallels LTP of the CA1 population spike response.