Literature DB >> 7284307

L(-)-10-Formyltetrahydrofolate is the cofactor for glycinamide ribonucleotide transformylase from chicken liver.

G K Smith, P A Benkovic, S J Benkovic.   

Abstract

It is shown that L(-)-10-formyltetrahydrofolate serves as the cofactor for glycinamide ribonucleotide transformylase from chicken liver. The utilization of L(-)-10-formyl-H4folate was not previously recognized, because L-(+)-10-formyl-H4folate is an excellent competitive inhibitor of the enzyme, Ki = 0.75 +/- 0.07 microM, and historically the transformylase assay was carried out with a mixture of diastereomers. The results are discussed in relation to the utilization of L(+)-5,10-methenyl-H4folate.

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Year:  1981        PMID： 7284307     DOI： 10.1021/bi00517a013

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  8 in total

1.  Multiple purine pathway enzyme activities are encoded at a single genetic locus in Drosophila.

Authors:  S Henikoff; M A Keene; J S Sloan; J Bleskan; R Hards; D Patterson
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

2.  Assignment of a third purine biosynthetic gene (glycinamide ribonucleotide transformylase) to human chromosome 21.

Authors:  R G Hards; S J Benkovic; M L Van Keuren; S L Graw; H A Drabkin; D Patterson
Journal:  Am J Hum Genet       Date:  1986-08       Impact factor: 11.025

3.  One-carbon metabolic pathway rewiring in Escherichia coli reveals an evolutionary advantage of 10-formyltetrahydrofolate synthetase (Fhs) in survival under hypoxia.

Authors:  Shivjee Sah; Srinivas Aluri; Kervin Rex; Umesh Varshney
Journal:  J Bacteriol       Date:  2014-12-01       Impact factor: 3.490

4.  Bioactivity of [6R]-5-formyltetrahydrofolate, an unusual isomer, in humans and Enterococcus hirae, and cytochrome c oxidation of 10-formytetrahydrofolate to 10-formyldihydrofolate.

Authors:  J E Baggott; C B Robinson; K E Johnston
Journal:  Biochem J       Date:  2001-02-15       Impact factor: 3.857

5.  Cofactor role for 10-formyldihydrofolic acid.

Authors:  J E Baggott; G L Johanning; K E Branham; C W Prince; S L Morgan; I Eto; W H Vaughn
Journal:  Biochem J       Date:  1995-06-15       Impact factor: 3.857

6.  Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase.

Authors:  Kyle C Strickland; L Alexis Hoeferlin; Natalia V Oleinik; Natalia I Krupenko; Sergey A Krupenko
Journal:  J Biol Chem       Date:  2009-11-20       Impact factor: 5.157

7.  Differences in methotrexate and 7-hydroxymethotrexate inhibition of folate-dependent enzymes of purine nucleotide biosynthesis.

Authors:  J E Baggott; S L Morgan; W H Vaughn
Journal:  Biochem J       Date:  1994-06-15       Impact factor: 3.857

8.  Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.

Authors:  J E Baggott; W H Vaughn; B B Hudson
Journal:  Biochem J       Date:  1986-05-15       Impact factor: 3.857
  8 in total

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