Literature DB >> 7284251

Disappearance of epidermal Langerhans cells during PUVA therapy.

P S Friedmann.   

Abstract

The numbers and morphological appearance of epidermal Langerhans cells (LCs) were studied in twenty-five patients with psoriasis receiving treatment with 8-methoxypsoralen (8-MOP) and long wavelength UV irradiation (UV-A) (PUVA). After a single exposure, LCs showed loss of fine dendritic processes. Repeated treatments resulted in a reduction of the number of LCs from the mean pretreatment value of 713/mm2 to less than 60/mm2 after seven treatments. The number of LCs remained low while treatment continued for up to 4 weeks. This finding may explain the impaired contact hypersensitivity observed in patients with psoriasis receiving PUVA therapy.

Entities:  

Mesh：

Year:  1981        PMID： 7284251     DOI： 10.1111/j.1365-2133.1981.tb01209.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN： 0007-0963            Impact factor:   9.302


  15 in total

1.  Epidermal T lymphocytes and dendritic cells in chronic plaque psoriasis: the effects of PUVA treatment.

Authors:  B S Baker; A F Swain; C E Griffiths; J N Leonard; L Fry; H Valdimarsson
Journal:  Clin Exp Immunol       Date:  1985-09       Impact factor: 4.330

2.  A semiquantitative light and electron microscopic analysis of histopathologic changes in photochemotherapy-induced freckles.

Authors:  L Kanerva; K M Niemi; J Lauharanta
Journal:  Arch Dermatol Res       Date:  1984       Impact factor: 3.017

3.  Effect of UV-irradiation on immunological and histochemical markers of Langerhans cells in normal appearing skin of psoriatic patients.

Authors:  U Tjernlund; L Juhlin
Journal:  Arch Dermatol Res       Date:  1982       Impact factor: 3.017

4.  PUVA therapy for psoriasis.

Authors:  H Baker
Journal:  J R Soc Med       Date:  1984-07       Impact factor: 5.344

5.  Epidermal Langerhans cell number and morphology during oral retinoid treatment.

Authors:  L Koulu; C T Jansén
Journal:  Arch Dermatol Res       Date:  1982       Impact factor: 3.017

6.  Fine structure of Merkel cells after PUVA treatment.

Authors:  L Kanerva; K M Niemi; J Lauharanta; A Lassus
Journal:  Arch Dermatol Res       Date:  1982       Impact factor: 3.017

7.  Antigenic stimulation during ultraviolet therapy in man does not result in immunological tolerance.

Authors:  P S Friedmann; S I White; S Parker; C Moss; J N Matthews
Journal:  Clin Exp Immunol       Date:  1989-04       Impact factor: 4.330

Review 8.  Risk of melanoma with psoralen/ultraviolet A therapy for psoriasis. Do the known risks now outweigh the benefits?

Authors:  B Lindelöf
Journal:  Drug Saf       Date:  1999-04       Impact factor: 5.606

9.  Cytokine expression in psoriatic skin lesions during PUVA therapy.

Authors:  A K Olaniran; B S Baker; D G Paige; J J Garioch; A V Powles; L Fry
Journal:  Arch Dermatol Res       Date:  1996-07       Impact factor: 3.017

10.  Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model.

Authors:  Germain J P Fernando; Xianfeng Chen; Tarl W Prow; Michael L Crichton; Emily J Fairmaid; Michael S Roberts; Ian H Frazer; Lorena E Brown; Mark A F Kendall
Journal:  PLoS One       Date:  2010-04-21       Impact factor: 3.240
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