Literature DB >> 7283740

Identification and determination of 2-thiothiazolidine-4-carboxylic acid in urine of workers exposed to carbon disulfide.

R van Doorn, L P Delbressine, C M Leijdekkers, P G Vertin, P T Henderson.   

Abstract

A compound was isolated from the urine of workers exposed to carbon disulfide during the production of rayon. The compound was identified as 2-thiothiazolidine-4-carboxylic acid (TTCA) by GC/MS and NMR. A HPLC method for the quantitative determination of TTCA was elaborated and applied to urine samples. The method allowed detection of TTCA concentrations in urine as low as 5 X 10(-7) M. No TTCA was detected in urine of workers occupationally exposed to organic solvents other than CS2. High concentrations of TTCA (upto 32 X 10(-5) M) were shown to be present in urine of spinners exposed to CS2 concentrations of approximately 100 mg/m3. It is suggested that the assay of urinary TTCA is suitable for detection of occupational exposure to CS2.

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Year:  1981        PMID： 7283740     DOI： 10.1007/BF00297130

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  12 in total

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Journal:  Prac Lek       Date:  1963-05

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Authors:  L F Chasseaud
Journal:  Adv Cancer Res       Date:  1979       Impact factor: 6.242

9.  Determination of thio compounds in urine of workers exposed to carbon disulfide.

Authors:  R van Doorn; C P Leijdekkers; P T Henderson; M Vanhoorne; P G Vertin
Journal:  Arch Environ Health       Date:  1981 Nov-Dec

10.  Ten-year coronary mortality of workers exposed to carbon disulfide.

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Journal:  Scand J Work Environ Health       Date:  1979-06       Impact factor: 5.024
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  13 in total

1.  Study on relationship between carbon disulfide exposure and symptoms and signs of nervous system in workers.

Authors:  Y Bi; N Tao; X Tan; F Wang; Y Li; Y Su
Journal:  J Tongji Med Univ       Date:  1999

Review 2.  An introduction to the clinical toxicology of volatile substances.

Authors:  R J Flanagan; M Ruprah; T J Meredith; J D Ramsey
Journal:  Drug Saf       Date:  1990 Sep-Oct       Impact factor: 5.606

3.  Accumulation of carbon disulphide metabolites.

Authors:  L van Poucke; C van Peteghem; M Vanhoorne
Journal:  Int Arch Occup Environ Health       Date:  1990       Impact factor: 3.015

4.  Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries.

Authors:  Lena S Jönsson; Karin Broberg; Ulf Bergendorf; Anna Axmon; Margareta Littorin; Bo A G Jönsson
Journal:  Int Arch Occup Environ Health       Date:  2007-02-28       Impact factor: 3.015

5.  Dietary habits, a non-negligible source of 2-thiothiazolidine-4-carboxylic acid and possible overestimation of carbon disulfide exposure.

Authors:  P Simon; T Nicot; M Dieudonné
Journal:  Int Arch Occup Environ Health       Date:  1994       Impact factor: 3.015

6.  Biological monitoring of workers occupationally exposed to carbon disulphide in a rayon plant in Brazil: validity of 2-thiothiazolidine-4-carboxylic acid (TTCA) in urine samples taken in different times, during and after the real exposure period.

Authors:  S Kitamura; F Ferrari; G Vides; D C Moreira Filho
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

7.  Preliminary evaluation of urinary 2-thio-thiazolidine-4-carboxylic-acid (TTCA) levels as a test for exposure to carbon disulfide.

Authors:  J Rosier; M Vanhoorne; R Grosjean; E Van de Walle; G Billemont; C Van Peteghem
Journal:  Int Arch Occup Environ Health       Date:  1982       Impact factor: 3.015

8.  Effect of cytochrome P450 isozyme induction and glutathione depletion on the metabolism of CS2 to TTCA in rats.

Authors:  H Kivistö; E Elovaara; V Riihimaki; A Aitio
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

9.  Relation between the iodine azide test and the TTCA test for exposure to carbon disulphide.

Authors:  J Rosier; G Billemont; C Van Peteghem; M Vanhoorne; R Grosjean; A Van de Walle
Journal:  Br J Ind Med       Date:  1984-08

10.  Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans.

Authors:  R T van Welie; P van Duyn; E K Lamme; P Jäger; B L van Baar; N P Vermeulen
Journal:  Int Arch Occup Environ Health       Date:  1991       Impact factor: 3.015
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