Literature DB >> 7283301

Underrepresentation of women in new drug trials.

E L Kinney, J Trautmann, J A Gold, E S Vesell, R Zelis.   

Abstract

Young women serve less frequently than young men as subjects in premarketing clinical drug trials. Moral, legal, and medical implications of this underrepresentation of women are considered. Risks of medical harm to female patients can increase because medication is withheld. Also, risks of toxicity increase when women receive certain new drugs only in the postmarketing phase. Remedies to increase participation of young, nonpregnant women in clinical trials are discussed.

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Year:  1981        PMID: 7283301     DOI: 10.7326/0003-4819-95-4-495

Source DB:  PubMed          Journal:  Ann Intern Med        ISSN: 0003-4819            Impact factor:   25.391


  4 in total

1.  Ethical considerations in the conduct of clinical pharmacokinetic studies.

Authors:  C K Svensson
Journal:  Clin Pharmacokinet       Date:  1989-10       Impact factor: 6.447

Review 2.  Women in clinical drug trials. An update.

Authors:  D L Schmucker; M S O'Mahony; E S Vesell
Journal:  Clin Pharmacokinet       Date:  1994-12       Impact factor: 6.447

Review 3.  Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs.

Authors:  A D Kashuba; A N Nafziger
Journal:  Clin Pharmacokinet       Date:  1998-03       Impact factor: 6.447

4.  The underrecognition of HIV infection in women in an inner-city emergency room.

Authors:  E E Schoenbaum; M P Webber
Journal:  Am J Public Health       Date:  1993-03       Impact factor: 9.308

  4 in total

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