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Literature DB >> 728322

The features of hepatic enzyme induction with glutethimide in man.

Abstract

1 Sequential measurements of D-glucaric acid excretion were made in six healthy volunteers before, during and after 3 weeks' daily medication with glutethimide 500 mg. 2 There was a rapid rise in D-glucaric acid excretion within 2 days of starting medication and a rapid decline when it was stopped. 3 Antipyrine clearance and indocyanine green clearance were measured before and at the end of the 3 weeks' medication. 4 There was a 55% increase in antipyrine clearance but no change in indocyanine green clearance. 5 There was no correlation between antipyrine clearance and D-glucaric acid excretion. 6 Glutethimide causes rapid enzyme induction in man without concomitant rise in hepatic blood flow.

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Year: 1978 PMID： 728322 PMCID： PMC1429696 DOI： 10.1111/j.1365-2125.1978.tb00877.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

21 in total

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Authors: J Hunter
Journal: J R Coll Physicians Lond Date: 1974-01

8 in total

Review 1. Assessment of the drug metabolism capacity of the liver.

Authors: B K Park
Journal: Br J Clin Pharmacol Date: 1982-11 Impact factor: 4.335

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Authors: B K Park; A M Breckenridge
Journal: Clin Pharmacokinet Date: 1981 Jan-Feb Impact factor: 6.447

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Authors: P E Lønning; S Kvinnsland; G Jahren
Journal: Cancer Chemother Pharmacol Date: 1984 Impact factor: 3.333

4. D-glucaric acid excretion in critical care patients--comparison with 6 beta-hydroxycortisol excretion and serum gamma-glutamyltranspeptidase activity and relation to multiple drug therapy.

Authors: G Heinemeyer; I Roots; P Lestau; H R Klaiber; R Dennhardt
Journal: Br J Clin Pharmacol Date: 1986-01 Impact factor: 4.335