Literature DB >> 728320

The effect on myocardial contractility of a new beta-adrenergic receptor blocking drug, penbutolol.

R P Sapru, P L Sharma.   

Abstract

1 The inotropic effect of penbutolol, a new beta-adrenergic receptor blocking drug, has been compared with that of propranolol in two similar groups of six subjects each. 2 Inotropic changes were assessed from changes in myocardial contractility index [LV dp-dt/11 T] as well as the slope of the regression line relating LV dp/dt to LVED during incremental pacing. 3 Penbutolol was found to have a significant negative inotropic effect of an order similar to that of propranolol in the respective doses studied.

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Year:  1978        PMID： 728320      PMCID： PMC1429691          DOI： 10.1111/j.1365-2125.1978.tb00875.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  17 in total

1.  MYOCARDIAL FORCE-VELOCITY RELATIONS STUDIED IN INTACT UNANESTHETIZED MAN.

Authors:  G GLICK; E H SONNENBLICK; E BRAUNWALD
Journal:  J Clin Invest       Date:  1965-06       Impact factor: 14.808

2.  Isometric time-tension relationships as an index of myocardial contractility.

Authors:  J H SIEGEL; E H SONNENBLICK
Journal:  Circ Res       Date:  1963-06       Impact factor: 17.367

3.  Hemodynamic determinants of the maximal rate of rise of left ventricular pressure.

Authors:  A G WALLACE; N S SKINNER; J H MITCHELL
Journal:  Am J Physiol       Date:  1963-07

4.  Studies on the first derivative of the ventricular pressure pulse in man.

Authors:  W L GLEASON; E BRAUNWALD
Journal:  J Clin Invest       Date:  1962-01       Impact factor: 14.808

5.  Long term treatment of moderate hypertension with penbutolol (Hoe 893d). I. Effects on blood pressure, pulse rate, catecholamines in blood and urine, plasma renin activity and urinary aldosterone under basal conditions and following exercise.

Authors:  B G Hansson; B Hökfelt
Journal:  Eur J Clin Pharmacol       Date:  1975-10-10       Impact factor: 2.953

6.  Comparative potency of intravenous penbutolol and propranolol in man.

Authors:  P L Sharma; R P Sapru
Journal:  Int J Clin Pharmacol Biopharm       Date:  1978-02

7.  [Phenbutolol (Hoe 893d), a new highly efficient -sympatholytic agent with long action duration].

Authors:  G Härtfelder; H Lessenich; K Schmitt
Journal:  Arzneimittelforschung       Date:  1972-05

8.  Effects of changing heart rate in man by electrical stimulation of the right atrium. studies at rest, during exercise, and with isoproterenol.

Authors:  J Ross; J W Linhart; E Brauwald
Journal:  Circulation       Date:  1965-10       Impact factor: 29.690

9.  [Penbutolol--a sinistrorotatory adrenergic beta-receptor blocking agent. Ergometer investigations in patients with angina pectoris].

Authors:  P Prahl; M Prahl
Journal:  Ugeskr Laeger       Date:  1973-05-17

10.  A comparative double-blind adjustable dose clinical trial of penbutolol and propranolol in angina pectoris.

Authors:  C V Bhirmanandan; J S Chadha; P L Sharma; P L Wahi
Journal:  J Assoc Physicians India       Date:  1977-06
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  3 in total

1.  Penbutolol (Hoe 893d) in primary hypertension. Blood pressure effects, tolerance and plasma concentrations.

Authors:  K P Ohman; J Asplund; S Landahl; B Liander
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

2.  Penbutolol: a preliminary review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris.

Authors:  R C Heel; R N Brogden; T M Speight; G S Avery
Journal:  Drugs       Date:  1981-07       Impact factor: 9.546

3.  Haemodynamic dose-response effects of i.v. penbutolol in angina pectoris.

Authors:  B Silke; S P Verma; M Hussain; G I Nelson; R C Okoli; S H Taylor
Journal:  Br J Clin Pharmacol       Date:  1983-11       Impact factor: 4.335
  3 in total

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