Literature DB >> 728112

The mechanism of haem degradation in vitro. Kinetic evidence for the formation of a haem-oxygen complex.

S B Brown, S E Thomas.   

Abstract

The rate of haem degradation in aqueous pyridine shows a saturation dependence on O2 concentration. CO competitively inhibits the reaction. This is evidence for formation of an iron-O2 complex and is consistent with an intramolecular pathway for haem degradation.

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Year:  1978        PMID： 728112      PMCID： PMC1186231          DOI： 10.1042/bj1760327

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  8 in total

Review 1.  The enzymatic formation of bilirubin.

Authors:  R Schmid; A F McDonagh
Journal:  Ann N Y Acad Sci       Date:  1975-04-15       Impact factor: 5.691

2.  180 studies of haem catabolism.

Authors:  S B Brown; R F King
Journal:  Biochem Soc Trans       Date:  1976       Impact factor: 5.407

3.  The structure of haem in pyridine/water mixtures and its implication in studies of haem catabolism.

Authors:  S B Brown; R F King
Journal:  Biochem J       Date:  1976-02-01       Impact factor: 3.857

4.  Stereospecific haem cleavage. A model for the formation of bile-pigment isomers in vivo and in vitro.

Authors:  S B Brown
Journal:  Biochem J       Date:  1976-10-01       Impact factor: 3.857

5.  The role of iron in haem degradation [proceedings].

Authors:  S B Brown; M S Grundy
Journal:  Biochem Soc Trans       Date:  1977       Impact factor: 5.407

6.  The mechanism of haem catabolism. A study of haem breakdown in spleen microsomal fraction and in a model system by 18O labelling and metal substitution.

Authors:  R F King; S B Brown
Journal:  Biochem J       Date:  1978-07-15       Impact factor: 3.857

7.  The mechanism of coupled oxidation of octaethylhaem to octaethylbiliverdin [proceedings].

Authors:  B D Chaney; S B Brown
Journal:  Biochem Soc Trans       Date:  1978       Impact factor: 5.407

8.  The mechanism of haem catabolism. Bilirubin formation in living rats by [18O]oxygen labelling.

Authors:  S B Brown; R F King
Journal:  Biochem J       Date:  1978-02-15       Impact factor: 3.857
  8 in total
  1 in total

1.  Estimation of Km values of enzymes requiring molecular O2 as a substrate.

Authors:  R H Strang
Journal:  Biochem J       Date:  1981-03-01       Impact factor: 3.857
  1 in total

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