| Literature DB >> 7281099 |
M J Smith, C W Turton, D N Mitchell, M Turner-Warwick, L M Morris, S D Lawler.
Abstract
HLA may influence the natural history of some diseases. HLA frequencies have been compared in 164 healthy control subjects, 50 patients with sarcoid lung fibrosis, and 37 patients with sarcoidosis that resolved spontaneously. B8 was increased significantly in the resolved group compared to both healthy control subjects (p less than 0.001) and the fibrotic group (p less than 0.01). The results support the findings of other investigators, and are consistent with the hypothesis that inherited host factors, perhaps related to immune response, influence the clinical expression of sarcoidosis.Entities:
Mesh：
Substances：
Year: 1981 PMID： 7281099 PMCID： PMC471495 DOI： 10.1136/thx.36.4.296
Source DB: PubMed Journal: Thorax ISSN： 0040-6376 Impact factor: 9.139