| Literature DB >> 7280966 |
L A Lawson, R A Blouin, R B Smith, R P Rapp, A B Young.
Abstract
A possible drug interaction between phenytoin and dexamethasone was evaluated by comparing serum phenytoin concentrations in 23 patients receiving both drugs with those of a control group of 15 patients receiving phenytoin only. Serum phenytoin concentrations obtained 24 hours after a loading dose of 11 mg per kilogram body weight administered intravenously and 13 mg/kg given intramuscularly were examined. The total amounts of dexamethasone administered during the 24-hour period ranged from 16 to 150 mg. The average serum phenytoin concentration was 17.28 +/- 3.49 micrograms/ml in patients receiving both drugs, as compared to 12.48 +/- 3.52 micrograms/ml in patients receiving only phenytoin (p less than 0.001). Our results suggest that serum phenytoin concentrations should be monitored in patients receiving concurrent dexamethasone therapy.Entities:
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Year: 1981 PMID： 7280966 DOI： 10.1016/s0090-3019(81)80054-7
Source DB: PubMed Journal: Surg Neurol ISSN： 0090-3019