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Literature DB >> 728033

The hypoxic, low-flow perfused rat heart: characterization as a model of global ischaemia.

A de Kock, A Lochner, J C Kotzé, W Gevers.

Abstract

In the study of the mechanism of mitochondrial damage in myocardial ischaemia, production of a small animal model of global ischaemia proved to be necessary. Thus, the effects of coronary flow rate, oxygen availability and substrate availability were studied on the functional capacity of mitochondria isolated from perfused rat hearts. The hypoxic, low-flow perfused heart eventually chosen was evaluated as a model of myocardial ischaemia by measuring tissue contents of high energy phosphate compounds and glycolytic intermediates and by assessing the effects of exogenous substrates on the above parameters.

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Year: 1978 PMID： 728033 DOI： 10.1007/bf01906530

Source DB: PubMed Journal: Basic Res Cardiol ISSN： 0300-8428 Impact factor: 17.165

20 in total

1. The oxygen uptake of the perfused rat heart.

Authors: R B FISHER; J R WILLIAMSON
Journal: J Physiol Date: 1961-09 Impact factor: 5.182

2. Mitochondrial oxidative phosphorylation in myocardial ischaemia: effects of glycerol, glucose and insulin on anoxic hearts perfused at low pressure.

Authors: A Lochner; J C Kotźe; W Gevers
Journal: J Mol Cell Cardiol Date: 1976-07 Impact factor: 5.000

3. Mechanisms of glycolytic inhibition in ischemic rat hearts.

Authors: M J Rovetto; W F Lamberton; J R Neely
Journal: Circ Res Date: 1975-12 Impact factor: 17.367

4. Effects of regional ischemia on metabolism of glucose and fatty acids. Relative rates of aerobic and anaerobic energy production during myocardial infarction and comparison with effects of anoxia.

Authors: L H Opie
Journal: Circ Res Date: 1976-05 Impact factor: 17.367

5. Mitochondrial biochemical changes and glucose-KCl-insulin solution in cardiac infarct.

Authors: E Calva; A Mújica; R Núñez; K Aoki; A Bisteni; D Sodi-Pallares
Journal: Am J Physiol Date: 1966-07

6. Structural and functional abnormalities in mitochondria isolated from ischemic dog myocardium.

Authors: R B Jennings; P B Herdson; H M Sommers
Journal: Lab Invest Date: 1969-06 Impact factor: 5.662

7. Comparison of the effects of anoxia and whole heart ischemia on carbohydrate utilization in isolated working rat hearts.

Authors: M J Rovetto; J T Whitmer; J R Neely
Journal: Circ Res Date: 1973-06 Impact factor: 17.367

The hypoxic, low-flow perfused rat heart: characterization as a model of global ischaemia.

1. The oxygen uptake of the perfused rat heart.

2. Mitochondrial oxidative phosphorylation in myocardial ischaemia: effects of glycerol, glucose and insulin on anoxic hearts perfused at low pressure.

3. Mechanisms of glycolytic inhibition in ischemic rat hearts.

4. Effects of regional ischemia on metabolism of glucose and fatty acids. Relative rates of aerobic and anaerobic energy production during myocardial infarction and comparison with effects of anoxia.

5. Mitochondrial biochemical changes and glucose-KCl-insulin solution in cardiac infarct.

6. Structural and functional abnormalities in mitochondria isolated from ischemic dog myocardium.

7. Comparison of the effects of anoxia and whole heart ischemia on carbohydrate utilization in isolated working rat hearts.

8. Effect of ethanol on metabolism and function of perfused rat heart.

9. Function, substrate supply, and metabolic content of rabbit heart perfused in situ.

10. Effect of coronary blood flow on glycolytic flux and intracellular pH in isolated rat hearts.

1. Substrate effects on mitochondrial function and tissue lipids in low-flow hypoxia of isolated perfused rat hearts.

2. Substrate effects on sarcolemmal permeability in the normoxic and hypoxic perfused rat heart.

3. Coronary vasoconstrictor and vasodilator actions of arachidonic acid in the isolated perfused heart of the rat.

4. The isolated perfused rat heart: a model for studying myocardial hypoxia or ischaemia.