Literature DB >> 727825

The effect of an in situ-produced oil shale processing water on metabolism.

K F Nelson, D S North, G R Payne, A D Anderson, R E Poulson, D S Farrier.   

Abstract

The effects of in situ-produced oil shale retort water on the metabolism of various substrates was studied both in vivo and in vitro. The induction observed in rats was classified as Type I due to an increase in metabolism of hexobarbital and ethylmorphine without subsequent increases in zoxazolamine metabolism. The maximal absorption of the cytochrome-P450-CO complex was observed to be 450 millimicron, also consistent with Type I inducers. Cytochrome P-450 levels were also significantly increased over controls.

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Year:  1978        PMID： 727825     DOI： 10.1007/bf02332055

Source DB:  PubMed          Journal:  Arch Environ Contam Toxicol        ISSN： 0090-4341            Impact factor:   2.804


  17 in total

1.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  Biochemical and pharmacological changes in the rat following chronic administration of morphine nalorphine and normorphine.

Authors:  J COCHIN; J AXELROD
Journal:  J Pharmacol Exp Ther       Date:  1959-02       Impact factor: 4.030

3.  The enzymatic metabolism of hexobarbital (evipal).

Authors:  J R COOPER; B B BRODIE
Journal:  J Pharmacol Exp Ther       Date:  1955-08       Impact factor: 4.030

4.  The fate of pentobarbital in man and dog and a method for its estimation in biological material.

Authors:  B B BRODIE; J J BURNS; L C MARK; P A LIEF; E BERNSTEIN; E M PAPPER
Journal:  J Pharmacol Exp Ther       Date:  1953-09       Impact factor: 4.030

5.  Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene.

Authors:  A P Alvares; G Schilling; W Levin; R Kuntzman
Journal:  Biochem Biophys Res Commun       Date:  1967-11-30       Impact factor: 3.575

6.  Guanine in cancer.

Authors:  S GRAFF; M ENGELMAN; H B GILLESPIE; A M GRAFF
Journal:  Cancer Res       Date:  1951-05       Impact factor: 12.701

7.  Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems.

Authors:  N E Sladek; G J Mannering
Journal:  Mol Pharmacol       Date:  1969-03       Impact factor: 4.436

8.  Studies on microsomal hydroxylation and the demonstration of a new carbon monoxide binding pigment in liver microsomes.

Authors:  R Kuntzman; W Levin; M Jacobson; A H Conney
Journal:  Life Sci II       Date:  1968-02-15

9.  Studies on the mechanism of hormone induction of alkaline phosphatase in human cell cultures, II. Rate of enzyme synthesis and properties of base level and induced enzymes.

Authors:  M J Griffin; R P Cox
Journal:  Proc Natl Acad Sci U S A       Date:  1966-09       Impact factor: 11.205

10.  Inhibition of drug metabolism. I. Kinetics of the inhibition of the N-demethylation of ethylmorphine by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and related compounds.

Authors:  M W Anders; G J Mannering
Journal:  Mol Pharmacol       Date:  1966-07       Impact factor: 4.436
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  1 in total

1.  Oil shale processing as a source of aquatic pollution: monitoring of the biologic effects in caged and feral freshwater fish.

Authors:  A Tuvikene; S Huuskonen; K Koponen; O Ritola; U Mauer; P Lindström-Seppä
Journal:  Environ Health Perspect       Date:  1999-09       Impact factor: 9.031
  1 in total

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