Inheritance of the Chediak-Higashi syndrome in cats.

The phenotypes with respect to the Chediak-Higashi syndrome (CHS) of 245 cats from 67 matings were analyzed. It was determined that the gene for feline CHS, like that in other species with CHS, is inherited in an autosomal recessive manner with complete penetrance. We propose the symbol ch for the gene for CHS in cats. Additional studies revealed enlarged periodic acid-Schiff positive granules in renal tubule cells in CHS cats, which provides further evidence of the homologous nature of CHS among the various species in which it occurs.