| Literature DB >> 7275839 |
Abstract
Extracts of the cephamycin C producer S. lactamdurans were found to possess cystathionine gamma-lyase activity (E.C. 4.4.1.1). This represents the first demonstration of this enzyme of the reverse transsulfuration pathway in a prokaryotic organism. A likely involvement of reverse transsulfuration in antibiotic synthesis is indicated by the fact that propargylglycine, a mechanism-based inhibitor of the gamma-lyase, is a strong inhibitor of cephamycin C production.Entities:
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Year: 1981 PMID： 7275839 DOI： 10.7164/antibiotics.34.583
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649