| Literature DB >> 7275832 |
G Albers-Schönberg, H Joshua, M B Lopez, O D Hensens, J P Springer, J Chen, S Ostrove, C H Hoffman, A W Alberts, A A Patchett.
Abstract
A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of HMG-CoA reductase, inhibition of sterol synthesis in cell cultures, and inhibition of cholesterol synthesis in vivo in rats.Entities:
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Year: 1981 PMID： 7275832 DOI： 10.7164/antibiotics.34.507
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649